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Science ; 168(3933): 844-5, 1970 May 15.
Article in English | MEDLINE | ID: mdl-5444059

ABSTRACT

The major metabolite of (-)-trans-Delta(8)-tetrahydrocannabinol observed in vivo and formed by hepatic microsomes in vitro is 11-hydroxy-trans-Delta(8)-tetrahydrocannabinol. The metabolite was identified spectroscopically and was synthesized from trans-Delta(8)-tetrahydrocannabinol. In tests with rats, the metabolite produced behavioral effects similar to those imparted by Delta(8)- and Delta(9)-tetrahydrocannabinol.


Subject(s)
Benzopyrans/metabolism , Animals , Behavior, Animal/drug effects , Benzopyrans/analysis , Benzopyrans/chemical synthesis , Cannabis , Chromatography, Thin Layer , Magnetic Resonance Spectroscopy , Microsomes, Liver/metabolism , Rabbits , Rats
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