[Primary carcinoma of Bartholin's glands with HPV 18 detection]. / Primäres Karzinom der Bartholinischen Drüse mit HPV-18-Nachweis.

A primary carcinoma of the Bartholin's gland is a rarely type of vulva-carcinoma. The patients median age are 55 years and the etiology of the carcinoma are still unknown. Viral influences are discussed. Most frequent types of carcinomas of Bartholin's gland are those of squamous cells and adenocarcinomas. This article reports on a 55 year old patient with a primary carcinoma of Bartholin's gland. The human papillomavirus 18 was detected by a polymerase chain reaction. The correct diagnosis was delayed because of an initial misinterpretation of the carcinoma as a Bartholin cyst, marsupialization and bad healing of the wound. The patient underwent a radical vulvectomy with bilateral inguinofemoral lymphonodectomy in combination with radiation therapy.

[Antithrombin III level in normal pregnancy and patients with pregnancy-induced hypertension]. / Antithrombin-III-Spiegel bei Normalschwangeren und Patientinnen mit schwangerschaftsinduzierter Hypertonie.

During pregnancy an increase of antithrombin III can be observed. In hypertensive pregnant women this increase may be smaller. This fact may be a sign of hypertension induced disseminated intravascular coagulation and important for prognosis and therapy of pregnancy-induced hypertension. We carried out estimations of antithrombin III by double determinations using radial immundiffusion. Antithrombin III levels were lower in patient with pregnancy-induced hypertension.

[Factor VIII-associated antigen/factor VIII ratio in pregnant patients with and without hypertension]. / Faktor VIII-assoziiertes Antigen/Faktor VIII-Ratio bei Graviden mit und ohne Hypertonus.

During pregnancy there is an elevation of factor VIII. In hypertensive pregnancy this increase may be smaller. On the other hand factor VIII associated antigen-factor VIII-ratio is said to be increased in these women compared with normotensive ones. There is a discussions about using these change for early detection of PIH. Estimations of factor VIII have been made chemically. Estimations of factor VIII associated antigen have been carried out immunologically. Factor VIII associated antigen-factor VIII-ratio was higher in pregnant women with hypertension than in normotensive ones.

[Treatment of fetal hemolytic disease using plasmapheresis]. / Therapie des Morbus haemolyticus fetalis mittels Plasmapherese.

Report about the therapy of severe Morbus haemolyticus fetalis in 15 pregnant women by plasmapheresis alone. Fetal survival rate was 67%. One of three children with hydrops fetalis survived. Plasmapheresis may be used in combination with intrauterine transfusion and improves treatment of Morbus haemolyticus fetalis.

[Intrauterine intraperitoneal transfusion controlled by ultrasound. A case report]. / Intrauterine intraperitoneale Transfusion unter Ultraschallkontrolle. Ein Fallbericht.

Two intrauterine transfusions in one fetus have been performed utilizing continuous ultrasound supervision by Sonolayer SSA-90 A in the 31st and 33rd gestational week.

[Results of prenatal amniotic fluid diagnosis in suspected hemolytic disease of newborn]. / Ergebnisse der pränatalen Fruchtwasserdiagnostik bei Verdacht auf Morbus haemolyticus fetalis.

759 amniotic fluid samples have been examined spectrophotometrically according to Liley and chemically for bilirubin from 286 patients with suspicion of morbus haemolyticus fetalis. The results obtained, gave the following findings for the procedure of Liley: sensitivity 75.0 per cent, specivity 96.5 per cent, accuracy 85.3 per cent, predictive value of positive test 95.6 per cent and predictive value of negative test 79.1 per cent and for the chemical test respectively: 88.2 per cent, 81.7 per cent, 85.0 per cent, 83.0 per cent and 87.2 per cent. A pathological delta E value is suspect of a serious erythroblastosis. But a serious morbus haemolyticus fetalis may be excluded with higher likelihood by concentration of bilirubin chemically determined below the pathological range then by correlated values of delta E. Finally we conclude that two different methods for amniotic fluid diagnostic are of higher predictability.

[Report of experiences in 20 years use of intrauterine fetal transfusion in severe Rh-induced hemolytic disease of newborn]. / Erfahrungsbericht über 20 Jahre der Anwendung der intrauterinen fetalen Transfusion bei schwerem Rh-bedingten Morbus haemolyticus fetalis.

136 intrauterine transfusions in 90 fetuses between the 25th and 34th gestational week with severe hemolytic disease because of Rh-incompatibility have been performed after a prenatal step by step diagnostic in the years 1967 till 1986. The reason of the immunization was mistransfusion or omitted immune prophylaxis in 25 cases. 25 from 67 live born children died. There were 23 still births. 34 from 43 fetuses without hydrops survived, but only 8 from 47 fetuses with hydrops. The survival rate over all was 46.7 per cent.

[Therapy of cervix insufficiency--cerclage or support pessary?]. / Therapie der Zervixinsuffizienz--Zerklage oder Stützpessar?

To evaluate the efficiency of cerclage or pessary a prospective random study has been done from 1982 to 1983. Pelvic score of Bishop and tocolysis index of Baumgarten were used to define the situation at the beginning. Success has been estimated with help of neonatal parameters (birth weight, Apgar score and RDS-morbidity) and final gestational week. Both methods are equal in their effects.

[Value of the oral glucose tolerance test for diagnosis of intrauterine fetal retardation]. / Wertigkeit des oralen Glukosetoleranztestes für die Diagnose der intrauterinen fetalen Retardierung.

Oral glucose tolerance test using 50 g glucose has been done in 76 pregnant women. The newborns were subdivided in 3 groups: under the 5., under the 10. and above the 10. weight percentile. The glucose tolerance test had no predictive value for the diagnosis of intrauterine growth retardation.

[Magnesium determination in maternal and umbilical cord serum following tocolysis with magnesium supplement]. / Magnesiumbestimmung im mütterlichen und Nabelschnurserum nach Tokolyse mit Magnesiumzusatz.

We carried out a tocolysis in 14 women with and in 13 women without magnesium and determined the magnesium level in maternal and cord serum. The magnesium determination could not give a declaration about the role of magnesium in diagnostic and therapy of preterm delivery.

[Effect of alpha-methyldopa (Dopegyt) on blood pressure in hypertensive pregnant patients]. / Einfluss von alpha-Methyldopa (Dopegyt) auf den Blutdruck hypertensiver Schwangerer.

Forty-three patients hospitalised for chronic hypertension or superimposed toxemia in late pregnancy were treated with Dopegyt-orally in constant dosage. Blood pressure dropped at the beginning of therapy. In the further course of treatment blood pressure re-increased in 14 patients, that other antihypertensive drugs had to be administered additionally. alpha-methyldopa alone is sufficient only in a part of the hypertensive patients.

[Amniocentesis with free needle guidance following pinpointing using ultrasonic compound scan]. / Amniozentese mit freier Nadelführung nach Ultrasehall-Compoundscan-Zielermittlung.

There is reported about 106 amniocenteses between 28th and 40th week of pregnancy after previous investigation and marking of the point of puncture on the abdomen of the pregnant woman by means of investigation the point with ultrasonic compoundscan. The angle of puncture method is found out and the maximum and minimum infiltration intensity. Complications have not been observed. That technique makes possible a high security for puncture and excellent puncture results.

[Blood coagulation studies of therapeutic abortion induced by 15-methyl-prostaglandin F2 alpha]. / Gerinnungsuntersuchungen bei 15-Methyl-Prostaglandin-F 2alpha-induzierten therapeutischen Abortus.

10 women with unwanted pregnancies in the first and second trimester were terminated by use of intramuscular injections of 15-Methyl-PGF2alpha. Studies of bleeding and recalcification time, platelet count, levels of heat-fibrin, prothrombin, partial thromboplastin time, platelet adhesiveness and heparinocytes were performed before treatment. 30 minutes, 4 and 8 hours after beginning of 15-Methyl-PGF2alpha-administration, 2 hours after the expulsion of the product of conception and 24 hours after first investigation. Prothrombin decreased during treatment with 15-Methyl-PGF2alpha and did not obtain the starting value 24 hours after first investigation. Platelet count showed an equal attitude. The time of recalcification increased continuous. Heparinocytes continuous decreased up to 2 hours after expulsion of the product of conception. 24 hours after first investigation a significant ascent was noticed. The results of the studies on coagulation did not indicate a strong injury of coagulation system. They suggest the positive estimation of termination of pregnancy in the first and second trimester with 15-Methyl-PGF2alpha.