ABSTRACT
BACKGROUND: A common postoperative complication after laparoscopic Roux-en-Y gastric bypass (LRYGB) is the development of marginal ulcers (MUs) at the gastrojejunal anastomosis. Several risk factors, such as smoking, seem to have an impact on the development of MUs. OBJECTIVE: Very little is known about how much smoking increases the risk. We therefore reviewed our patients regarding their smoking behavior and the development of MUs after LRYGB. SETTING: Primary care hospital and a university hospital. METHODS: This study included 249 patients who underwent LRYGB surgery between 2010 and 2015 with at least 2 years of follow-up at a single institution. This retrospective analysis focused on the development of marginal ulcers after LRYGB, the time of appearance, and possible risk factors. RESULTS: A total of 27 (10.8%) patients in this study developed MUs. The majority of MUs (66.7%) occurred within the first postoperative year. Smoking is an independent and statistically significant predictor of the development of MUs with a 4.6-fold greater risk (P = .003). Light, moderate, and heavy daily smokers have the same rate of MUs (17.4% versus 17.1% versus 17.9%, respectively). Light smokers with <10 cigarettes per day are at significantly increased risk for MUs compared with nonsmokers (17.4 versus 4.2%, respectively; P = .027). Former and current smokers are at comparable risks for MUs (13.3% versus 17.5%, respectively; P = .685). CONCLUSION: The described incidence of 10.8% shows that marginal ulcers are one of the most important and frequent complications after LRYGB. Smoking at every intensity is associated with an extraordinary risk of MU formation after LRYGB and therefore, smoking cessation before bariatric surgery must be strongly recommended.
