[The inhalation of beta stimulators. Effect of the inhaled aerosol deposited in the oropharynx and in the bronchial tree]. / Die Inhalation von beta-Stimulatoren Wirkung des im Oropharynx und des im Bronchialbaum angelagerten Anteils des Inhalats

Inhaled aerosols are predominatly deposited in the oropharynx and only a minor portion penetrates into the sublaryngeal airways. The effectiveness of both components of an orciprenaline aerosol was tested in 12 asthmatics. For this purpose they were given an inhalation on one day and, on the next, the entire oropharynx was sprayed with the inhalant. Evaluation of the corresponding bronchodilator effects was based on repeated measurements of specific airway conductance. The results show that the inhalation is about 6 times as effective as the spray, and thus prove the superiority of inhalation therapy over oral or peroral medication with beta-stimulants in the treatment of bronchial asthma.