1.
Bioorg Med Chem
; 6(11): 2013-27, 1998 Nov.
Article
in English
| MEDLINE
| ID: mdl-9881093
ABSTRACT
Extensive molecular modelling studies, including conformational analysis and the comparison of molecular electrostatic potential distributions, wee used to evaluate structural parameters of new antagonists containing acyclic replacements of the N = C-N imidazole region. The synthesis and the biological screening of a series of acyl biphenyltetrazole derivatives were planned and realized to gain an insight into the structure-activity relationships of this unusual class of Angiotensin II antagonists.