ABSTRACT
A novel HLA-DPB1 allele, named HLA-DPB1*647:01, identified in a leukemia patient.
Subject(s)
Alleles , HLA-DP beta-Chains/genetics , Leukemia/genetics , Amino Acid Sequence , Base Sequence , Codon/genetics , HLA-DP beta-Chains/chemistry , Humans , ItalyABSTRACT
Two novel alleles, HLA-A*31:125 and HLA-B*44:269, are described in Italian bone marrow donors.
Subject(s)
Alleles , Bone Marrow/metabolism , Histocompatibility Antigens Class I/genetics , Tissue Donors , Base Sequence , Exons/genetics , Humans , ItalyABSTRACT
The HLA-B*18:122 allele showed four nucleotide differences from HLA-B*18:01:01:01.
Subject(s)
Alleles , Exons , HLA-B18 Antigen/genetics , Polymorphism, Single Nucleotide , Tissue Donors , Amino Acid Substitution , Base Sequence , Bone Marrow Transplantation , Codon/chemistry , Gene Expression , Genome, Human , HLA-B18 Antigen/immunology , Histocompatibility Testing , Humans , Introns , Polymerase Chain Reaction , Sequence Alignment , Sequence Analysis, DNAABSTRACT
One nucleotide substitution at residue 142 of the HLA-DRB1*13:01:01 results in a new allele, HLA-DRB1*13:215.
Subject(s)
Alleles , Exons , HLA-DRB1 Chains/genetics , Polymorphism, Single Nucleotide , Tissue Donors , Amino Acid Sequence , Amino Acid Substitution , Base Sequence , Codon/chemistry , HLA-DRB1 Chains/immunology , Hematopoietic Stem Cell Transplantation , Histocompatibility Testing , Humans , Italy , Polymerase Chain Reaction , Sequence Alignment , Sequence Analysis, DNAABSTRACT
A novel class I human leukocyte antigen allele HLA-A*24:309 is described.
Subject(s)
Alleles , Bone Marrow , HLA-A Antigens/genetics , Tissue Donors , Humans , Italy , MaleABSTRACT
HLA-B*18:108 has two nucleotide changes from B*18:01:01:02 at nt 430 where A â G and nt 431 where G â A.
Subject(s)
Alleles , Exons/genetics , Genetic Loci , HLA-B Antigens/genetics , Introns/genetics , Sequence Analysis, DNA , Amino Acid Sequence , Base Sequence , Female , HLA-B Antigens/chemistry , Humans , Molecular Sequence Data , Sequence AlignmentABSTRACT
A novel HLA-A allele, HLA-A*68:105, was detected by sequence-based typing (SBT) in an Italian bone marrow donor. It differs from HLA-A*68:01:02 at five nucleotides, three intronic, nt 699 T->G (intron 2), nt 705 T->C (intron 2) and nt 2770 G->A (intron 7), and two located in exon 3, at positions 726 A-G (codon 94 Ile->Val) and 733 T-G (codon 97 Arg->Met), respectively.
Subject(s)
Alleles , Genome, Human/genetics , HLA-A Antigens/genetics , Sequence Analysis, DNA , Base Sequence , Exons/genetics , Humans , Molecular Sequence Data , Sequence AlignmentABSTRACT
A novel HLA-DPB1 allele, named DPB1*296:01, was identified in the Thai mother of a hematologic patient.
Subject(s)
Alleles , HLA-DP beta-Chains/genetics , Base Sequence , Bone Marrow , Female , Histocompatibility Testing , Humans , Molecular Sequence Data , Sequence Analysis, DNA , Thailand , Tissue DonorsABSTRACT
A newly identified allele, named HLA B*15:276, differs from B*15:01:01:01 by the single nucleotide substitution 511T-C at codon 147 (Trp â Arg) in exon 3.
