ABSTRACT
This paper briefly reviews the evidence supporting the reality of healing as a scientifically-attested phenomenon, the techniques and mechanisms of healing and the potential value of this therapy if it were developed and integrated into the medical services. The need for further extensive research is indicated and strategies for such research are suggested.
Subject(s)
Mental Healing , HumansABSTRACT
Several polyhydroxy alkaloids, including the eight presently known to occur in plants, have been compared as inhibitors of mouse gut digestive disaccharidases. The indolizidine castanospermine inhibited all activities tested, but others showed a selectivity which could be of value in studies of carbohydrate digestion and errors of metabolism.
Subject(s)
Alkaloids/pharmacology , Disaccharidases/antagonists & inhibitors , Indolizines , Intestines/enzymology , Pyrrolidines , Animals , Chemical Phenomena , Chemistry , Female , Imino Furanoses , In Vitro Techniques , Intestinal Mucosa/enzymology , Mannitol/analogs & derivatives , Mice , SwainsonineSubject(s)
Colon/enzymology , Intestine, Small/enzymology , Mast Cells/pathology , Nematode Infections/blood , Phospholipases/metabolism , Animals , Blood Cell Count , Cell Count , Colon/pathology , Female , Intestine, Small/pathology , Nematode Infections/pathology , Nippostrongylus , Rats , Rats, Inbred StrainsABSTRACT
The rate of glucose absorption and metabolism and the associated fluid transfer of the small intestine of rats was measured in vitro using an everted sac technique after daily doses of 0, 5, 25 or 225 infective larvae of Nippostrongylus for periods of one to five weeks. Though there were occasional significant changes in the physiology of the intestine there were no obvious patterns or trends with respect to time at any infection level. This differs from the response after a single infection. The possible role of immune adaptation and reduced immunogenicity of the worms during repeated infections is considered.
Subject(s)
Glucose/metabolism , Intestinal Absorption , Nematode Infections/metabolism , Animals , Intestinal Mucosa/metabolism , Larva , Male , Nippostrongylus , RatsABSTRACT
A challenge infection of Nippostrongylus brasiliensis in immune rats resulted in an earlier onset of intestinal glucose malabsorption and increased glucose metabolism compared with rats receiving a primary infection. Intestinal absorption and metabolism recovered to control levels earlier during a secondary infection. The pattern of changes in absorption and metabolism was probably related to host immunological activity.
Subject(s)
Glucose/metabolism , Intestinal Absorption , Intestine, Small/metabolism , Nematode Infections/metabolism , Animals , Female , Immunologic Memory , Intestinal Mucosa/metabolism , Nematode Infections/immunology , Nippostrongylus , Rats , Time FactorsABSTRACT
1. The Pasteur effect was shown after 15 min but not after 30 min incubation of jejunal rings from normal rats. 2. During 15-30 min incubation, the rate of anaerobic lactate production decreased, while aerobic lactate production remained unchanged. Thus oxygen was necessary to maintain the functional integrity of the tissue during this period. 3. After infection with either Nematospiroides dubius or Nippostrongylus brasiliensis, the Pasteur effect could not usually be shown, mainly due to a reduced rate of anaerobic lactate production. 4. The possible relationship of the loss of the Pasteur effect to the immune response is discussed.
