ABSTRACT
One case of rare maternal-fetal immunization in a patient affected by Cooley's anemia, is reported. The opportunity for a complete characterization of the blood group and for a search for maternal antibodies in patients with a history of multiple blood transfusions is stressed.
Subject(s)
Anemia, Hemolytic, Congenital/etiology , Antigens/analysis , Blood Group Antigens/analysis , Blood Group Antigens/immunology , Duffy Blood-Group System/analysis , Duffy Blood-Group System/immunology , Thalassemia/immunology , Adult , Arrestin , Coombs Test , Female , Humans , Maternal-Fetal Exchange , PregnancyABSTRACT
The measurement of the tissue concentrations of cyclic adenosine monophosphate (cAMP) in human endometrium shows that the levels of the nucleotide vary during the menstrual cycle, being 11.4 +/- (SE) 2.5 and 37.7 +/- (SE) 10.1 pmol/mg protein in the proliferative and secretory phase, respectively. The individual determinations of cAMP are significantly correlated to the estradiol/progesterone blood concentration ratio: by this means we obtained a superimposable distribution with the results of histologic examination suggesting that the hormones have a direct action in determining the cAMP levels in this tissue. The relevance of these observations for the physiology of the endometrium is discussed.
