Subject(s)
Community-Acquired Infections , Methicillin-Resistant Staphylococcus aureus , Staphylococcal Infections , Humans , Staphylococcal Infections/microbiology , Staphylococcal Infections/drug therapy , Staphylococcal Infections/mortality , Community-Acquired Infections/microbiology , Community-Acquired Infections/mortality , Community-Acquired Infections/drug therapy , Fatal Outcome , MaleSubject(s)
Biomarkers , Intensive Care Units , Survivors , Humans , Prospective Studies , Survivors/psychology , Critical Illness/psychologySubject(s)
Parkinson Disease , Social Stigma , Humans , Parkinson Disease/psychology , Biomedical ResearchABSTRACT
This is the second part of the Brazilian S20 mental health report. The mental health working group is dedicated to leveraging scientific insights to foster innovation and propose actionable recommendations for implementation in Brazil and participating countries. In addressing the heightened mental health challenges in a post-pandemic world, strategies should encompass several key elements. This second part of the S20 Brazilian Mental Health Report will delve into some of these elements, including: the impact of climate change on mental health, the influence of environmental factors on neurodevelopmental disorders, the intersection of serious mental illness and precision psychiatry, the co-occurrence of physical and mental disorders, advancements in biomarkers for mental disorders, the utilization of digital health in mental healthcare, the implementation of interventional psychiatry, and the design of innovative mental health systems integrating principles of innovation and human rights. Reassessing the treatment settings for psychiatric patients within general hospitals, where their mental health and physical needs are addressed should be prioritized in mental health policy. As the S20 countries prepare for the future, we need principles that stand to advance innovation, uphold human rights, and strive for the highest standards in mental health care.
Subject(s)
Diaphragm , Intensive Care Units , Quadriceps Muscle , Tracheostomy , Ventilator Weaning , Humans , Male , Female , Middle Aged , AgedSubject(s)
Fibrinolytic Agents , Thrombolytic Therapy , Tissue Plasminogen Activator , Humans , Tissue Plasminogen Activator/therapeutic use , Tissue Plasminogen Activator/administration & dosage , Fibrinolytic Agents/therapeutic use , Thrombolytic Therapy/methods , Reperfusion/methods , Recombinant Proteins/therapeutic useSubject(s)
Cerebral Palsy , Humans , Cerebral Palsy/physiopathology , Sleep Quality , Digestion/physiologyABSTRACT
New hippocampal neurons are continuously generated in the adult human brain. Several studies have demonstrated that the proliferation of hippocampal cells is strongly influenced by a variety of stimuli, including pesticides exposure. These effects are particularly important because neurogenesis dysregulation could be associated with the decline of neuronal and cognitive functions and the possible development of neuropsychiatric disorders.
Novos neurônios hipocampais são gerados continuamente no cérebro humano adulto. Vários estudos têm demonstrado que a proliferação de células do hipocampo é influenciada por uma variedade de estímulos, incluindo a exposição a pesticidas. Estes efeitos são particularmente importantes porque a desregulação da neurogênese pode estar associada ao declínio das funções neuronais e cognitivas e ao possível desenvolvimento de doenças neuropsiquiátricas.
Subject(s)
Hippocampus , Neurogenesis , Neurons , Pesticides , Pesticides/toxicity , Humans , Hippocampus/drug effects , Hippocampus/physiology , Neurogenesis/drug effects , Neurogenesis/physiology , Neurons/drug effects , Neurons/physiology , AnimalsSubject(s)
Death, Sudden , Parkinson Disease , Humans , Parkinson Disease/mortality , Death, Sudden/etiology , Male , Female , Aged , Hospital Mortality , Middle Aged , Risk Factors , Brazil/epidemiology , Aged, 80 and overSubject(s)
COVID-19 , Cytokines , Humans , COVID-19/cerebrospinal fluid , COVID-19/complications , Cytokines/cerebrospinal fluid , Cytokines/blood , Male , Female , Middle Aged , SARS-CoV-2 , AgedABSTRACT
Aging populations worldwide are placing age-related diseases at the forefront of the research agenda. The therapeutic potential of natural substances, especially propolis and its components, has led to these products being promising agents for alleviating several cellular and molecular-level changes associated with age-related diseases. With this in mind, scientists have introduced a contextual framework to guide future aging research, called the hallmarks of aging. This framework encompasses various mechanisms including genomic instability, epigenetic changes, mitochondrial dysfunction, inflammation, impaired nutrient sensing, and altered intercellular communication. Propolis, with its rich array of bioactive compounds, functions as a potent functional food, modulating metabolism, gut microbiota, inflammation, and immune response, offering significant health benefits. Studies emphasize propolis' properties, such as antitumor, cardioprotective, and neuroprotective effects, as well as its ability to mitigate inflammation, oxidative stress, DNA damage, and pathogenic gut bacteria growth. This article underscores current scientific evidence supporting propolis' role in controlling molecular and cellular characteristics linked to aging and its hallmarks, hypothesizing its potential in geroscience research. The aim is to discover novel therapeutic strategies to improve health and quality of life in older individuals, addressing existing deficits and perspectives in this research area.
