ABSTRACT
PURPOSE: To evaluate the effect of catheter directed thrombolysis (CDT) on heart rate (HR) in patients with sinus tachycardia and acute pulmonary embolism (PE). METHODS: A retrospective chart review was performed for patients who underwent CDT with tPA for acute massive or submassive PE between 12/2009 and 2/2020. Included were patients who presented with tachycardia at the time of initiation of CDT. Patients with chronic PE, atrial fibrillation, beta blocker therapy, adjunctive endovascular therapy, systemic thrombolysis, or who expired before conclusion of CDT were excluded. HR was measured approximately every hour during CDT. Graphs were plotted of HR as a function of CDT duration. Two interventional radiologists identified the point of plateau (POP) on the graph where CDT had maximized its benefit in decreasing the patient's HR. Discrepancies were adjudicated by a third interventional radiologist and the median of the 3 measurements was selected. The primary endpoint was the duration of CDT from initiation until the POP. RESULTS: 48 patients were included (52.5 ± 14.7 years, 56.3% female). The POP occurred after 13.1 ± 6.1 hours, by which point HR had been reduced from 110 ± 9.2 bpm to 88 ± 10.6 bpm. Sinus tachycardia was not resolved in 10 patients even though they achieved maximal improvement in HR after 11.3 ± 6.7 hours. CONCLUSION: Patients presenting with sinus tachycardia related to acute PE achieved maximal, sustained reduction in heart rate from CDT, after approximately 13 hours of infusion. Patients who did not resolve their tachycardia by that point in time were unlikely to resolve it by the conclusion of CDT.
Subject(s)
Fibrinolytic Agents/administration & dosage , Heart Rate , Pulmonary Embolism/drug therapy , Tachycardia, Sinus/physiopathology , Thrombolytic Therapy , Tissue Plasminogen Activator/administration & dosage , Adult , Aged , Female , Fibrinolytic Agents/adverse effects , Humans , Male , Middle Aged , Pulmonary Embolism/complications , Pulmonary Embolism/diagnosis , Retrospective Studies , Tachycardia, Sinus/diagnosis , Tachycardia, Sinus/etiology , Thrombolytic Therapy/adverse effects , Time Factors , Tissue Plasminogen Activator/adverse effects , Treatment OutcomeABSTRACT
This article reports experiments assessing how general threats to social order and severity of a crime can influence punitiveness. Results consistently showed that when participants feel that the social order is threatened, they behave more punitively toward a crime perpetrator, but only when severity associated with a crime was relatively moderate. Evidence is presented to suggest that people can correct-at least to a degree-for the "biasing" influence of these inductions. Finally, threats to social order appear to increase punitiveness by arousing a retributive desire to see individuals pay for what they have done, as opposed to a purely utilitarian desire to deter future wrongdoing. The authors suggest that individuals sometimes act as intuitive prosecutors when ascribing punishment to an individual transgressor based on their perception of general societal control efficacy.
