1.
Mol Divers
; 1(2): 125-34, 1996 Feb.
Article
in English
| MEDLINE
| ID: mdl-9237202
ABSTRACT
The solid phase synthesis of libraries containing a 1,3,4,6-tetrasubstituted-2,5-diketo-1,4-piperazine scaffold (DKP) or a 3,4,6-trisubstituted-2,5-diketo-1,4-morpholine scaffold (DKM) from alpha-bromocarboxylic acids and amines is described. Using a design strategy which we refer to as divergent library design, both templates were prepared from a common intermediate. The general utility of this synthetic route in creating novel, non-peptidyl chemical libraries is discussed.
Subject(s)
Directed Molecular Evolution/methods , Morpholines/chemical synthesis , Piperazines/chemical synthesis , Chemistry, Organic , Chromatography, High Pressure Liquid , Drug Design , Methods , Morpholines/chemistry , Organic Chemistry Phenomena , Piperazines/chemistry , Resins, Synthetic
2.
Br Med J
; 1(6158): 271, 1979 Jan 27.
Article
in English
| MEDLINE
| ID: mdl-421074
3.
Br Med J
; 1(6104): 53, 1978 Jan 07.
Article
in English
| MEDLINE
| ID: mdl-620167
4.
Br Med J
; 1(6004): 284, 1976 Jan 31.
Article
in English
| MEDLINE
| ID: mdl-1247827
5.
Proc R Soc Med
; 66(8): 784-7, 1973 Aug.
Article
in English
| MEDLINE
| ID: mdl-4542595
Subject(s)
Physical Therapy Modalities , Arthritis, Rheumatoid/therapy , Attitude to Health , Costs and Cost Analysis , Cryosurgery , Diathermy , Drug-Related Side Effects and Adverse Reactions , Electric Stimulation Therapy , Exercise Therapy , Hot Temperature , Humans , Infrared Rays/therapeutic use , Knee , Middle Aged , Osteoarthritis/therapy , Ultrasonic Therapy , Ultraviolet Therapy
6.
Physiotherapy
; 57(7): 322-5, 1971 Jul.
Article
in English
| MEDLINE
| ID: mdl-5314572
Subject(s)
Electric Stimulation Therapy , Pelvis , Urinary Incontinence/therapy , Humans , Muscle Contraction
7.
Rheumatol Phys Med
; 11(2): 87, 1971 May.
Article
in English
| MEDLINE
| ID: mdl-5580203
8.
Physiotherapy
; 55(8): 302-5, 1969 Aug.
Article
in English
| MEDLINE
| ID: mdl-5306576
9.
Ann Phys Med
; Suppl: 126-8, 1966.
Article
in English
| MEDLINE
| ID: mdl-4895005