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1.
Curr Cardiol Rev ; 14(4): 245-253, 2018.
Article in English | MEDLINE | ID: mdl-30095058

ABSTRACT

BACKGROUND: Ageing is associated with an inexorable decline in cardiac and vascular function, resulting in an increased risk of Cardiovascular Disease (CVD). Lifestyle factors such as exercise have emerged as a primary therapeutic target in the prevention of CVD, yet older individuals are frequently reported as being the least active, with few meeting the recommended physical activity guidelines. In contrast, well trained older individuals (Masters athletes) have superior functional capacity than their sedentary peers and are often comparable with young non-athletes. Therefore, the 'masters' athlete may be viewed as a unique non-pharmacological model which may allow researchers to disentangle the inexorable from the preventable and the magnitude of the unavoidable 'true' reduction in cardiac function due to ageing. CONCLUSION: This review examines evidence from studies which have compared cardiac structure and function in well trained older athletes, with age-matched controls but otherwise healthy.


Subject(s)
Athletes/psychology , Cardiovascular Physiological Phenomena/genetics , Exercise/physiology , Aged , Aged, 80 and over , Aging , Humans , Male , Middle Aged
2.
Endocr Connect ; 6(7): 430-436, 2017 Oct.
Article in English | MEDLINE | ID: mdl-28794164

ABSTRACT

High-intensity interval training (HIIT) improves peak power output (PPO) in sedentary aging men but has not been examined in masters endurance athletes. Therefore, we investigated whether a six-week program of low-volume HIIT would (i) improve PPO in masters athletes and (ii) whether any change in PPO would be associated with steroid hormone perturbations. Seventeen male masters athletes (60 ± 5 years) completed the intervention, which comprised nine HIIT sessions over six weeks. HIIT sessions involved six 30-s sprints at 40% PPO, interspersed with 3 min active recovery. Absolute PPO (799 ± 205 W and 865 ± 211 W) and relative PPO (10.2 ± 2.0 W/kg and 11.0 ± 2.2 W/kg) increased from pre- to post-HIIT respectively (P < 0.001, Cohen's d = 0.32-0.38). No significant change was observed for total testosterone (15.2 ± 4.2 nmol/L to 16.4 ± 3.3 nmol/L (P = 0.061, Cohen's d = 0.32)), while a small increase in free testosterone occurred following HIIT (7.0 ± 1.2 ng/dL to 7.5 ± 1.1 ng/dL pre- to post-HIIT (P = 0.050, Cohen's d = 0.40)). Six weeks' HIIT improves PPO in masters athletes and increases free testosterone. Taken together, these data indicate there is a place for carefully timed HIIT epochs in regimes of masters athletes.

4.
Pediatr Obes ; 11(4): 292-8, 2016 08.
Article in English | MEDLINE | ID: mdl-26251875

ABSTRACT

BACKGROUND: It is unclear whether the hypertriglyceridemic waist phenotype (HTWP) can be used to identify those at most risk of cardiometabolic disorders. OBJECTIVES: The utility of the HTWP as a useful predictor of cardiometabolic risk in youth stratified by body mass index was assessed. METHODS: Three hundred and eighty-seven children (12-17.5 years) were used within this cross-sectional study. Participants were classified as normal weight or overweight/obese according to the International Obesity Task Force criteria. The HTWP phenotype was defined as having a waist circumference ≥90th percentile for age and gender with concomitant triglyceride concentrations ≥1.24 mmol L(-1) . Cardiometabolic risk profiles were compared using MANCOVA. RESULTS: Normal weight participants with the HTWP had significantly higher levels of C-reactive protein 2.6 ± 0.4 vs. 1.6 ± 0.3 mg L(-1) (P < 0.05) and cardiometabolic risk scores (1.3 ± 0.3 vs. -0.7 ± 0.2 and 2.1 ± 0.4 vs. -0.5 ± 0.2; both P < 0.05) compared with those of a normal weight without the HTWP. Overweight/obese participants with the HTWP had significantly higher C-reactive protein levels (3.5 ± 0.6 vs. 2.6 ± 0.5; P < 0.05) as well as both cardiometabolic risk scores (1.6 ± 0.6 vs. 0.9 ± 0.2 and 2.2 ± 0.6 vs. 0.8 ± 0.2; both P < 0.001) when compared with overweight/obese participants without the HTWP. CONCLUSIONS: The HTWP may serve as a simple and clinically useful approach to identify youth at increased cardiometabolic risk.


Subject(s)
Body Mass Index , Cardiovascular Diseases/diagnosis , Hypertriglyceridemic Waist/complications , Overweight/complications , Pediatric Obesity/complications , Adolescent , Biomarkers/blood , Cardiovascular Diseases/etiology , Child , Cross-Sectional Studies , Female , Humans , Male , Phenotype , Risk Assessment/methods , Risk Factors , Waist Circumference
5.
Biol Sport ; 32(4): 307-13, 2015 Nov.
Article in English | MEDLINE | ID: mdl-26681833

ABSTRACT

The present study examined the physiological impact of a school based sprint interval training (SIT) intervention in replacement of standard physical education (SPE) class on cardio-respiratory fitness (CRF) and glucose homeostasis during the semester following summer vacation. Participants (n=49) were randomly allocated to either intervention (SIT; n=26, aged 16.9 ± 0.3 yrs) or control group who underwent standard physical education (SPE; n=23, aged 16.8 ± 0.6 yrs). CRF (VO2max) and glucose homeostasis were obtained prior-to and following 7 weeks of SIT exercise. Significant group x time interaction was observed for CRF (P < 0.01) with non-significant trends for fasting insulin (P= 0.08), and HOMA-IR (P=0.06). CRF decreased (P < 0.01) in SPE such that POST intervention CRF was significantly lower (P< 0.05) in SPE. Fasting plasma glucose (P < 0.01), insulin (P< 0.01) and HOMA-IR (P< 0.01) increased significantly amongst SPE. The main finding of the present study is that 7-weeks of SIT exercise is an effective method of maintaining (but not improving) CRF and fasting insulin homeostasis amongst school-going adolescents. SIT exercise demonstrates potential as a time efficient physiological adjunct to standard PE class in order to maintain CRF during the school term.

6.
J Sci Med Sport ; 6(3): 307-12, 2003 Sep.
Article in English | MEDLINE | ID: mdl-14609147

ABSTRACT

The literature regarding the blood pressure response to AAS use is equivocal. In addition, there is currently little data available on the Rate Pressure Product (RPP) response to anabolic androgenic steroids (AAS) use. The experimental aim of this study was to investigate the effects of AAS administration in combination with resistance training on blood pressure and rate pressure product in male amateur bodybuilders and compare the results with a morphologically matched, resistance trained control group. Subjects were divided into two groups (n=16 AAS users; n=16 controls). Systolic and Diastolic Blood Pressure, RPP. Resting Heart Rate and Body Composition measurements were obtained before (Pre), during (During) and 6-8 weeks following (Post) the AAS cycle in the AAS users with similar time intervals for the control group. No significant cardiovascular or morphological changes in the control group were found throughout the study. Significant increases in both diastolic (P<0.01) and mean arterial blood pressures (P<0.05) were found from Pre to Post cycle in the AAS group. RPP also increased significantly (P<0.01) from pre to post AAS cycle. All cardiovascular parameters returned to normal baseline measurements between 6 and 8 weeks post cycle. No blood pressure measurements throughout the study were consistent with clinically defined hypertension. The findings indicate that the AAS group exhibited significant increases in standard cardiovascular measurements compared with the control bodybuilders, and provides a contraindication to AAS use especially in borderline hypertensives.


Subject(s)
Anabolic Agents/therapeutic use , Androgens/therapeutic use , Blood Pressure/drug effects , Heart Rate/drug effects , Steroids/therapeutic use , Adult , Anthropometry , Follow-Up Studies , Humans , Male , Weight Lifting/physiology
7.
J Public Health Med ; 23(3): 195-7, 2001 Sep.
Article in English | MEDLINE | ID: mdl-11585191

ABSTRACT

A recent report suggested that some folic acid preparations available in the United States failed to meet the specifications for dissolution specified by the US Pharmacopoeia (USP), of 70 per cent drug release in the first hour of testing. The Teratology Society recommends that women of childbearing age should take a daily supplement of 400 microg folic acid when they are trying to conceive, to reduce the risk of foetal neural tube defects. The consequence of this failure to meet the USP requirements may be that an inadequate dose of folate may be absorbed and thus the expected level of protection against neural tube defects not afforded. The purpose of the present study was to examine a number of brands of folic acid (400 microg), available commercially in the United Kingdom, for compliance with the British Pharmacopoeia (BP) test for dissolution. Ten tablets (or capsules) from each of 11 brands were tested using dissolution apparatus compliant with BP requirements, using 0.1 M sodium hydroxide as the dissolution medium. The results indicated that four of the brands failed to release 70 per cent of the nominal drug content in the first hour of test and thus did not comply with the test. Two of the seven brands that passed the test went on to release more than 150 per cent of the nominal 400 microg drug content. These results highlight the problems of dose uniformity and the potential health risks of slow dissolution and under-dosing in commercially available folic acid dosage forms.


Subject(s)
Dietary Supplements/standards , Folic Acid/pharmacokinetics , Folic Acid/standards , Pharmacopoeias as Topic/standards , Absorption , Calibration , Female , Folic Acid/administration & dosage , Guideline Adherence , Humans , Neural Tube Defects/prevention & control , Pregnancy , Spectrophotometry, Ultraviolet , State Medicine , Tablets/chemistry , United Kingdom
8.
Am J Cardiol ; 88(1): 53-8, 2001 Jul 01.
Article in English | MEDLINE | ID: mdl-11423058

ABSTRACT

To identify new echocardiographic indexes of long-axis function that might differentiate between pathologic and physiologic left ventricular (LV) hypertrophy, we compared 60 subjects with different types of LV hypertrophy (group I: 15 patients with hypertrophic cardiomyopathy, group II: 15 patients with systemic hypertension, and group III: 30 athletes) with 20 normal subjects (group IV). The peak velocities of mitral annular motion at 4 sites were measured from the apex by tissue Doppler echocardiography. There were no differences in mean age and global ejection fraction between groups. Groups I and II had lower long-axis systolic and early diastolic velocities than the athletes (p <0.01) for all 4 sites. The best differentiation of pathologic from physiologic hypertrophy was provided by a mean systolic annular velocity <9 cm/s (sensitivity 87%, specificity 97%). Heterogeneity of annular velocities discriminated between group I and group II. Thus, long-axis systolic and early diastolic velocities are decreased in patients with pathologic hypertrophy, but preserved in athletes. These simple new echocardiographic parameters can differentiate between pathologic and physiologic hypertrophy.


Subject(s)
Echocardiography, Doppler , Hypertension/diagnostic imaging , Hypertrophy, Left Ventricular/diagnostic imaging , Sports/physiology , Adult , Analysis of Variance , Cardiomyopathy, Hypertrophic/diagnostic imaging , Cardiomyopathy, Hypertrophic/physiopathology , Diagnosis, Differential , Female , Humans , Hypertension/physiopathology , Hypertrophy, Left Ventricular/physiopathology , Logistic Models , Male , Middle Aged , Sensitivity and Specificity
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