1.
Org Lett
; 3(8): 1113-6, 2001 Apr 19.
Article
in English
| MEDLINE
| ID: mdl-11348172
ABSTRACT
[structure: see text]. The important biological secondary messenger NO can be generated from exogenous nitrovasodilators and NO donors. Nitrate esters are nitrovasodilators and NO mimetics, believed to be biotransformed to NO in vivo. On the basis of a mechanistic hypothesis, nitrates have been synthesized that release NO at significant rates in neutral aqueous solution in the presence only of added thiol. The novel masked beta-mercaptonitrates reported (SS-nitrates), provide information on possible sulfhydryl-dependent biotransformation mechanisms for nitrates in clinical use.
Subject(s)
Esters/chemistry , Nitric Oxide/chemistry , Electrochemistry , Models, Chemical , Sulfhydryl Compounds/chemistry
2.
Rev Med Chir Soc Med Nat Iasi
; 92(3): 593-6, 1988.
Article
in Romanian
| MEDLINE
| ID: mdl-3249875
Subject(s)
Air Pollutants, Occupational/poisoning , Dimethylamines/urine , Ethylamines/poisoning , Methylamines/poisoning , Occupational Diseases/urine , Air Pollutants, Occupational/analysis , Blood Proteins/analysis , Chronic Disease , Ethylamines/analysis , Humans , Methylamines/analysis , Occupational Diseases/blood , Occupational Diseases/chemically induced , Urea/blood
3.
Rev Med Chir Soc Med Nat Iasi
; 91(3): 553-6, 1987.
Article
in Romanian
| MEDLINE
| ID: mdl-3445059