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G Ital Med Lav Ergon ; 34(3 Suppl): 565-7, 2012.
Article in Italian | MEDLINE | ID: mdl-23405717

ABSTRACT

The GGT enzyme, considered for years only as a marker of liver disease and alcohol abuse, has now revealed a risk of death for many causes. Through a molecular exclusion chromatography on FPLC system (Fast Protein Liquid Chromatography), it is possible to discriminate four fractions of GGT, defined according to the molecular weight: big-GGT, medium-GGT, small-GGT and free-GGT. The objective was to study the preventing meaning of GGT fractions for asbestos-related diseases. This study was conducted on 129 workers previously exposed to asbestos, 22 patients affected by Malignant Pleural Mesothelioma and 107 healthy workers. Our data demonstrated a statistical significant correlation between the fraction free-GGT with the presence of MPM, suggesting a possible role for this molecule as a biomarker for MPM diagnosis. However, being a preliminary study, further studies are warranted to confirm our results.


Subject(s)
Asbestosis/blood , Occupational Diseases/blood , Occupational Exposure/adverse effects , gamma-Glutamyltransferase/blood , Humans , Male , Middle Aged
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