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The computation of simulated endplate potentials.

Ginsborg, B L; McLachlan, E M; Martin, A R; Searl, J W.

Proc R Soc Lond B Biol Sci ; 213(1191): 233-42, 1981 Oct 14.

Article in English | MEDLINE | ID: mdl-6120516

ABSTRACT

A method is described for computing simulated subthreshold responses (.e. endplate potentials) for the Falk-Fatt (1964) cable model of a muscle fibre due to a punctate change in ionic conductance. The method has been applied to a comparison of the Falk-Fatt and classical models. Comparison with experimental results suggests that the model is adequate to account for the response of the mouse muscle fibre, in which the endplate is highly localized. For frog muscle there are larger discrepancies, which may be due to the extended endplate in this species.

Subject(s)

Motor Endplate/physiology , Neuromuscular Junction/physiology , Synaptic Membranes/physiology , Animals , Electric Conductivity , In Vitro Techniques , Membrane Potentials , Mice , Models, Biological , Time Factors

On the determination of the concentration over a sphere with a barrier layer.

Ginsborg, B L; Searl, J W.

J Theor Biol ; 82(3): 521-4, 1980 Feb 07.

Article in English | MEDLINE | ID: mdl-6102623

Subject(s)

Models, Neurological , Neurotransmitter Agents/pharmacology , Synaptic Transmission/drug effects , Diffusion , Time Factors

ABSTRACT

Subject(s)

Subject(s)

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