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Bioorg Med Chem Lett ; 15(22): 4898-906, 2005 Nov 15.
Article in English | MEDLINE | ID: mdl-16165355

ABSTRACT

A novel class of anthranilic diamides has been discovered with exceptional insecticidal activity on a range of Lepidoptera. These compounds have been found to exhibit their action by release of intracellular Ca2+ stores mediated by the ryanodine receptor. The discovery, synthesis, structure-activity, and biological results are presented.


Subject(s)
Insecticides/chemistry , Insecticides/pharmacology , Ryanodine Receptor Calcium Release Channel/metabolism , ortho-Aminobenzoates/chemistry , ortho-Aminobenzoates/pharmacology , Amination , Animals , Calcium/metabolism , Insecta/drug effects , Molecular Structure , Structure-Activity Relationship , ortho-Aminobenzoates/classification
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