1.
Bioorg Med Chem Lett
; 15(23): 5257-61, 2005 Dec 01.
Article
in English
| MEDLINE
| ID: mdl-16168640
ABSTRACT
We report the synthesis and biological activity of a series of 2-cyano-4-fluoro-1-thiovalylpyrrolidine inhibitors of DPP-IV. Within this series, compound 19 provided a potent, selective, and orally active DPP-IV inhibitor which demonstrated a very long duration of action in both rat and dog.
