Introduction of a Novel Nano Sized N-Sulfonated Brönsted Acidic Homogeneous Catalyst for the Promotion of the Synthesis of 2H-Indazolo[2,1-b]Phthalazine-1,6,11(13H)-Triones.

In this research work, 4,4'-(butane-1,4-diyl)bis(1-sulfo-1,4-diazabicyclo[2.2.2]octane-1,4-diium) tetrachloride (NS-C4(DABCO-SO3H)2 · 4Cl) as a new nano-sized N-sulfonic acid was prepared and characterized using different types of spectroscopic methods including FT-IR, 1H NMR, 13C NMR, XRD, TGA and SEM analysis. This new reagent was efficiently used as catalyst for the promotion of the one-pot synthesis of 2H-indazolo[2,1-b]phthalazine-1,6,11(13H)-triones derivatives, as a class of biologically active compounds with important pharmaceutical properties, under solvent-free conditions during short reaction times in high yields.

Facile and Efficient Synthesis of Tetrahydrobenzimidazo [2,1-b]Quinazolin-1(2H)-One Derivatives Using Brönsted Acidic Ionic Liquid Immobilized on Nanoporous Na+-Montmorillonite.

In this work, an efficient and green procedure have been described for the synthesis of tetrahydrobenzimidazo[2,1-b]quinazolin-1(2H)-one derivatives using nanoporous sodium montmorillonite clay (Na+-MMT) modified with 1-methyl-3-(trimethoxysilylpropyl)-imidazolium hydrogen sulfate (Na+-MMT-[pmim]HSO4). The procedure gave the products in excellent yields in very short reaction times under solvent-free condition. Also this catalyst can be reused for six times without considerable loss of its catalytic activity.