ABSTRACT
Hyperreactio luteinalis is a benign, pregnancy-related condition with cystic enlargement of the ovaries and elevated androgen. However, only one-third of patients manifest as maternal virilisation and rarely does it cause fetal virilisation. Here, we report a virilised baby girl born to a virilised mother because of hyperreactio luteinalis. This case illustrates our management to maternal and fetal virilisation.
Subject(s)
Ovarian Cysts , Pregnancy Complications , Pregnancy , Female , Humans , Mothers , Ovarian Cysts/diagnostic imaging , Ovarian Cysts/surgery , Ovarian Cysts/complications , Virilism/etiologyABSTRACT
A total of 16 cases of congenital fibrosarcoma have been reported from 1975 to March 2015. Five of the 16 had abnormal fusion between erythroblast transformation specific translocation variant 6 and neurotrophin recptor gene neurotrophic tyrosine kinase, receptor, type 3 (ETV6-NTRK3); in another five out of 16 this was absent, and six were not tested. All were managed by surgical resection but none involved metastasis. Herein we report the case of a newborn baby girl with congenital fibrosarcoma negative for ETV6-NTRK3 gene fusion, who presented with ileal perforation and positive resection margin. She had rapid recurrence with lymph node metastasis treated with postoperative chemotherapy. There was no further recurrence at >3 years of follow up.
Subject(s)
Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Fibrosarcoma/drug therapy , Ileal Neoplasms/drug therapy , Intestine, Small/surgery , Jejunal Neoplasms/drug therapy , Neoplasm Recurrence, Local/drug therapy , Antineoplastic Agents/therapeutic use , Chemotherapy, Adjuvant , Colectomy , Female , Fibrosarcoma/congenital , Fibrosarcoma/pathology , Fibrosarcoma/surgery , Humans , Ileal Neoplasms/congenital , Ileal Neoplasms/pathology , Ileal Neoplasms/surgery , Infant, Newborn , Jejunal Neoplasms/congenital , Jejunal Neoplasms/pathology , Jejunal Neoplasms/surgery , Lymphatic Metastasis , Neoplasm Recurrence, Local/pathology , Neoplasm Recurrence, Local/surgeryABSTRACT
A teenage girl presented with galactorrhoea and moderate hyperprolactinaemia. She was subsequently diagnosed to have acute lymphoblastic leukaemia. Further investigations supported the presence of ectopic prolactin production as suggested by the presence of prolactin mRNA in the patient's marrow at diagnosis. Both the ectopic prolactin mRNA and galactorrhoea eventually resolved upon disease remission after treatment.
