ABSTRACT
Assembling pieces of the standard model of the immune system, a saver system subset is proposed, comprising a continuously active circulating subsystem of saver cells and saver bodies which inspect every cell and antigen and saves/interrupts from self attack.
Subject(s)
Immune System/physiology , Models, Biological , Animals , Autoantibodies , Female , Humans , Immune Tolerance , In Vitro Techniques , Lymphocyte Activation , Male , Transplantation ImmunologyABSTRACT
This report summarizes our experience with nonsurgical ovum transfer at Harbor-UCLA Medical Center. In 29 attempts, 12 ova have been recovered and transferred. Two ongoing intrauterine recipient pregnancies have resulted from this preliminary research. There were two complications: one ectopic pregnancy in a recipient woman and one retained pregnancy in a donor woman who aborted spontaneously.
Subject(s)
Embryo Transfer/methods , Infertility, Female/therapy , Adult , Embryo Transfer/adverse effects , Female , Humans , Insemination, Artificial , Male , PregnancySubject(s)
Infertility, Female , Oocyte Donation , Pregnancy , Zygote/transplantation , Female , Humans , Insemination, Artificial/methods , MaleSubject(s)
Infertility, Female , Zygote/transplantation , Adult , Female , Humans , Insemination, Artificial, Homologous , Male , Methods , Tissue DonorsABSTRACT
This study investigated the effect of ketamine on myocardial function. In dogs the drug was infused directly into the left main coronary artery. The concentration chosen was similar to the peak concentration found following a bolus intravenous injection. A mild depression of inotropic state was found which recovered completely after stopping the infusion. Myocardial depression was confirmed in a guinea pig Langendorff preparation. No changes in high energy phosphates were found in these hearts after 45-60 minutes of perfusion with ketamine in the perfusion medium. This study confirms that myocardial depression occurs with ketamine but suggests that it is unlikely to be of clinical significance. Depletion of high energy phosphates did not seem to be the cause of the depression.
Subject(s)
Ketamine/pharmacology , Myocardial Contraction/drug effects , Adenosine Triphosphate/metabolism , Anesthesia, Intravenous , Animals , Depression, Chemical , Dogs , Guinea Pigs , Hemodynamics/drug effects , In Vitro Techniques , Myocardium/metabolism , Perfusion , Phosphocreatine/metabolismABSTRACT
In a canine preparation designed to separate myocardial from peripheral cardiovascular effects of the drug. It was found that thiopentone produced minimal depression of the heart. Only in much greater concentrations was significant depression found. It is concluded that the cardiovascular effects of thiopentone i.v. are not a direct effect on the heart.
