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1.
Prothrombinase: recognition and developments.
Seegers, W H.
Adv Exp Med Biol ; 281: 93-6, 1990.
Article in English | MEDLINE | ID: mdl-2102628

Subject(s)
Prothrombin/metabolism , Thrombin/metabolism , Thromboplastin/metabolism , Animals , Cattle , Humans , Kinetics , Methods , Thromboplastin/analysis
2.
A tribute to Marion I. Barnhart.
Seegers, W H.
Ann N Y Acad Sci ; 509: xi-xii, 1987.
Article in English | MEDLINE | ID: mdl-3322128

Subject(s)
Hematology/history , History, 20th Century , Michigan , Schools, Medical/history
3.
Postclotting fates of thrombin.
Seegers, W H.
Semin Thromb Hemost ; 12(3): 181-3, 1986 Jul.
Article in English | MEDLINE | ID: mdl-3775386

ABSTRACT

During the clotting of blood, prothrombin is virtually all converted to thrombin. By contrast, Factor X is not. Large quantities of thrombin are inhibited by plasma and platelet AT III (heparin cofactor I), by heparin cofactor II, and by fibrin. Lesser quantities function in various reactions in which thrombin specificity is modified for greater effectiveness. Some thrombin binds to platelets as well as blood vessel endothelial cells, but the latter facts were not included herein.


Subject(s)
Blood Coagulation , Thrombin/metabolism , Animals , Antithrombin III/metabolism , Factor X/metabolism , Glycoproteins/metabolism , Heparin Cofactor II , Humans , Prothrombin/metabolism
4.
Marion I. Barnhart (23 September, 1921-23 December, 1985).
Seegers, W H.
Thromb Res ; 42(4): 427-32, 1986 May 15.
Article in English | MEDLINE | ID: mdl-3520942

Subject(s)
Bibliographies as Topic , History, 20th Century , Humans , Middle Aged , Physiology/history , United States
5.
Prothrombinase in alpha-thrombin formation.
Seegers, W H.
Thromb Res ; 26(4): 303-5, 1982 May 15.
Article in English | MEDLINE | ID: mdl-6896773

Subject(s)
Factor V/metabolism , Factor X/metabolism , Factor Xa , Thrombin/biosynthesis , Enzyme Precursors/metabolism , Hemostasis , Thrombin/metabolism
6.
Enhanced enzyme activity in concentrated salt solutions.
Teng, C M; Seegers, W H.
Experientia ; 38(3): 403-4, 1982 Mar 15.
Article in English | MEDLINE | ID: mdl-7075742

Subject(s)
Factor X/pharmacology , Thrombin/metabolism , Trypsin/metabolism , Ammonium Sulfate/pharmacology , Animals , Cattle , Citrates/pharmacology , Citric Acid , Kinetics , Osmolar Concentration
7.
Thrombin, factor Xa, and trypsin in factor X activation.
Teng, C M; Sakuragawa, N; Seegers, W H.
New Istanbul Contrib Clin Sci ; 13(3): 135-42, 1982.
Article in English | MEDLINE | ID: mdl-7155814

Subject(s)
Factor X/metabolism , Thrombin/metabolism , Trypsin/metabolism , Animals , Cattle , Factor Xa
8.
A personal perspective on hemostasis and thrombosis (1937-1981).
Seegers, W H.
Semin Thromb Hemost ; 7(3-4): 177-307, 1981 Dec.
Article in English | MEDLINE | ID: mdl-7034202

Subject(s)
Hemostasis , Thrombosis/history , Amino Acid Sequence , Animals , Antithrombin III/metabolism , Blood Coagulation , Blood Platelets , Factor V/metabolism , Factor X/metabolism , Fibrinogen/metabolism , History, 20th Century , Humans , Plasminogen/metabolism , Prothrombin/isolation & purification , Research/history , Thrombin/isolation & purification
9.
Agkistrodon acutus snake venom inhibits prothrombinase complex formation.
Teng, C M; Seegers, W H.
Thromb Res ; 23(3): 255-63, 1981 Aug 01.
Article in English | MEDLINE | ID: mdl-7302928

Subject(s)
Factor V/biosynthesis , Factor X/biosynthesis , Snake Venoms/pharmacology , Animals , Binding Sites , Calcium/pharmacology , Enzyme Precursors/metabolism , Factor V/pharmacology , Factor X/antagonists & inhibitors , Factor X/pharmacology , Factor Xa , Phospholipids/pharmacology , Prothrombin/metabolism , Rabbits , Snakes
10.
Activation of factor X and thrombin zymogens in 25% sodium citrate solution.
Teng, C M; Seegers, W H.
Thromb Res ; 22(1-2): 203-12, 1981.
Article in English | MEDLINE | ID: mdl-7292440

Subject(s)
Citrates/pharmacology , Enzyme Precursors/metabolism , Factor X/metabolism , Prothrombin/metabolism , Citric Acid , Enzyme Activation/drug effects , Factor X/biosynthesis , Factor Xa , Thrombin/biosynthesis , Thrombin/metabolism
11.
Production of factor X and factor Xa variants with thrombin, acutin and by autolysis.
Teng, C M; Seegers, W H.
Thromb Res ; 22(1-2): 213-20, 1981.
Article in English | MEDLINE | ID: mdl-7027525

Subject(s)
Endopeptidases/metabolism , Factor X/metabolism , Thrombin/metabolism , Animals , Autolysis , Cattle , Electrophoresis, Polyacrylamide Gel , Factor Xa , Molecular Weight
12.
Three aspects of prothrombin activation related to protein M, ecarin, acutin, meizothrombin 1 and prethrombin 2.
Seegers, W H; Teng, C M; Ghosh, A; Novoa, E.
Ann N Y Acad Sci ; 370: 453-67, 1981.
Article in English | MEDLINE | ID: mdl-7023325

Subject(s)
Endopeptidases/pharmacology , Glycoproteins/pharmacology , Protein Precursors , Prothrombin/pharmacology , Viper Venoms/pharmacology , Animals , Autolysis , Cattle , Enzyme Precursors/pharmacology , Esterases/metabolism , Humans , Peptide Fragments/metabolism , Prothrombin/metabolism , Thrombin/biosynthesis , Thrombin/pharmacology
13.
Radioimmunoassays for human prothrombin fragments: development and implementation.
Walz, D A; Love, J N; Seegers, W H; Brown, T R.
Ann N Y Acad Sci ; 370: 398-413, 1981.
Article in English | MEDLINE | ID: mdl-6943965

Subject(s)
Enzyme Precursors/analysis , Peptide Fragments , Prothrombin/analysis , Adsorption , Animals , Antigen-Antibody Reactions , Antigens , Blood Coagulation , Body Fluids/analysis , Enzyme Precursors/urine , Female , Humans , Immune Sera/pharmacology , Protein Precursors/analysis , Protein Precursors/urine , Prothrombin/urine , Rabbits , Radioimmunoassay
14.
Production of prothrombin fragment 1-44 with acutin and some effects on thrombin generation.
Teng, C M; Seegers, W H.
Thromb Res ; 20(2): 271-9, 1980 Oct 15.
Article in English | MEDLINE | ID: mdl-7010664

Subject(s)
Endopeptidases/pharmacology , Prothrombin/biosynthesis , Thrombin/biosynthesis , Animals , Cattle , Electrophoresis, Polyacrylamide Gel , Enzyme Precursors/metabolism , Enzyme Precursors/pharmacology , Peptides/isolation & purification , Prothrombin/metabolism
15.
Note on the preparation of bovine thrombin.
Ghosh, A; Seegers, W H.
Thromb Res ; 20(2): 281-3, 1980 Oct 15.
Article in English | MEDLINE | ID: mdl-7010665

Subject(s)
Thrombin/isolation & purification , Animals , Blood Coagulation Factors/metabolism , Calcium Chloride/pharmacology , Cattle , Endopeptidases/pharmacology , Imidazoles , Prothrombin/pharmacology , Thrombin/biosynthesis
16.
Preparation of bovine prethrombin 2: use of Acutin and activation with prothrombinase or Ecarin.
Seegers, W H; Teng, C M; Novoa, E.
Thromb Res ; 19(1-2): 11-20, 1980.
Article in English | MEDLINE | ID: mdl-7003799

Subject(s)
Endopeptidases/pharmacology , Enzyme Precursors/isolation & purification , Prothrombin/isolation & purification , Thromboplastin/pharmacology , Viper Venoms/pharmacology , Animals , Cattle , Prothrombin/metabolism , Prothrombin/pharmacology
17.
Mechanisms of alpha-thrombin and beta-thrombin-E formation: use of ecarin for isolation of meizothrombin 1.
Novoa, E; Seegers, W H.
Thromb Res ; 18(5): 657-68, 1980 Jun 01.
Article in English | MEDLINE | ID: mdl-6998042

Subject(s)
Endopeptidases/pharmacology , Enzyme Precursors/isolation & purification , Thrombin/biosynthesis , Thrombin/isolation & purification , Viper Venoms/pharmacology , Animals , Blood Coagulation , Electrophoresis, Polyacrylamide Gel , Enzyme Precursors/metabolism , Enzyme Precursors/pharmacology , Factor X/pharmacology , Prothrombin/pharmacology , Snake Venoms , Thrombin/metabolism , Thrombin/pharmacology
18.
Protein M and the activation of dicoumarol induced atypical prothrombin.
Seegers, W H; Ghosh, A; Malhotra, O.
Thromb Res ; 18(1-2): 131-7, 1980.
Article in English | MEDLINE | ID: mdl-6157217

Subject(s)
Blood Proteins/physiology , Dicumarol/pharmacology , Prothrombin/physiology , Animals , Cattle , Humans , Thrombin/biosynthesis
19.
The activation of factor X and factor X beta with factor VII or protein M.
Seegers, W H; Ghosh, A.
Thromb Res ; 17(3-4): 501-6, 1980.
Article in English | MEDLINE | ID: mdl-6989015

Subject(s)
Factor VII/pharmacology , Factor X/metabolism , Factor X/pharmacology , Glycoproteins/pharmacology , Animals , Calcium/pharmacology , Cattle , Immunosorbent Techniques , Prothrombin Time , Thromboplastin/pharmacology
20.
Activation of prothrombin and factor X: function of previously unrecognized plasma protein.
Seegers, W H; Ghosh, A.
Thromb Res ; 17(1-2): 71-81, 1980.
Article in English | MEDLINE | ID: mdl-6154984

Subject(s)
Factor X , Prothrombin , Animals , Blood Proteins/isolation & purification , Cattle , Dicumarol/pharmacology , Factor VII Deficiency/blood , Factor X/isolation & purification , Prothrombin/isolation & purification , Thrombin/biosynthesis
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