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1.
Eur Spine J ; 22(11): 2552-7, 2013 Nov.
Article in English | MEDLINE | ID: mdl-23989746

ABSTRACT

PURPOSE: The Myelopathy Disability Index and the Neck Disability Index are widely used to assess outcome in cervical spine surgery. Short Form (SF) 36 is a generic measure of health which can be used to measure health gains across a wide variety of conditions. The aim of the current study is to assess long-term outcomes using these measures in a cohort of patients with cervical spondylotic myelopathy (CSM). METHODS: Cohort study with prospective data collection. Patients with CSM being offered decompressive surgery were asked to complete a set of generic and condition-specific outcome measures. This was repeated post-operatively at 3, 12, 24 and 60 months. SF-36 was used as a generic outcome measure and the Myelopathy Index, Neck Disability Score and visual analogue scores for arm, neck and hand pain, paraesthesia and dysthaesia were used as condition-specific outcome measures. RESULTS: Significant improvements in all outcome measures were seen in 70% of the cohort. For SF-36, pre-operative scores were lower than age-matched controls in all domains and significant improvements were seen 3 months following surgery. This improvement in outcome was maintained at 5 years follow-up in approximately two-thirds of those with initial improvement. CONCLUSION: We have used generic and condition-specific outcome measures of health and shown that in patients with CSM treated surgically, up to 70% can expect improvement in their quality of life. These outcome measures are easy to collect and provide objective evidence of changes in quality of life and disability and can help quantify the potential health gains that can be achieved.


Subject(s)
Spinal Cord Diseases/surgery , Spondylosis/surgery , Aged , Cohort Studies , Female , Humans , Male , Middle Aged , Prospective Studies , Quality of Life , Spinal Cord Diseases/etiology , Spondylosis/complications , Treatment Outcome
2.
Br J Neurosurg ; 21(4): 389-95, 2007 Aug.
Article in English | MEDLINE | ID: mdl-17676460

ABSTRACT

Establishing standardized methods to assess outcome is needed to measure the effectiveness of surgery in relieving symptoms and improving quality of life. We prospectively studied 203 patients undergoing primary lumbar discectomy. Data was collected before surgery, at 3 months postoperatively and at long-term follow-up (12-60 months, median 24) using both disease-specific (visual analogue scores, Roland-Morris disability scales, and Hospital Anxiety and Depression scales) and generic (SF-36) instruments. Continued significant symptomatic benefit was observed to long-term assessment and the health gains in this patient group compared favourably with other elective surgical procedures. We have used this data to validate the SF-36 for use in this context and we recommend that SF36 should be used as a sole measure of outcome in routine practice, as well as in future studies.


Subject(s)
Diskectomy/methods , Intervertebral Disc Displacement/surgery , Lumbar Vertebrae/surgery , Adolescent , Adult , Aged , Aged, 80 and over , Cohort Studies , Female , Humans , Intervertebral Disc Displacement/pathology , Male , Middle Aged , Pain Measurement/methods , Pain, Postoperative/etiology , Paresthesia/etiology , Postoperative Complications/etiology , Prospective Studies , Surveys and Questionnaires , Treatment Outcome
4.
Br J Neurosurg ; 20(1): 36-9, 2006 Feb.
Article in English | MEDLINE | ID: mdl-16698607

ABSTRACT

Patients undergoing neurosurgical intervention may require different types of organized rehabilitation. A prospective study was performed of the care needs of neurosurgical inpatients between the ages of 16 and 70 years who were in acute wards for more than 2 weeks. Only 58% of bed occupancy days were devoted to essential acute neurosurgical ward management. This figure was even lower for patients admitted with subarachnoid haemorrhage (36%) or traumatic brain injury (38%). Overall, 21% of bed days would have more appropriately spent in 'rapid access'/acute rehabilitation beds, 13% in 'active participation' rehabilitation beds and 5% in cognitive/behavioural rehabilitation units. Addressing this unmet need would increase the availability of acute neurosurgery beds, without needing to build and staff more neurosurgery wards.


Subject(s)
Bed Occupancy/statistics & numerical data , Craniocerebral Trauma/rehabilitation , Neurosurgery/statistics & numerical data , Adolescent , Adult , Aged , Health Services Needs and Demand , Humans , Length of Stay , Long-Term Care/statistics & numerical data , Middle Aged , National Health Programs , Prospective Studies , United Kingdom
5.
Emerg Med J ; 23(2): 128-32, 2006 Feb.
Article in English | MEDLINE | ID: mdl-16439742

ABSTRACT

OBJECTIVES: To develop standards of care for head injury and thereby identify and prioritize areas of the service needing development; to report the findings from a survey of compliance with such standards in the Eastern region of UK. METHODS: The standards were collaboratively developed through an inclusive and iterative process of regional surveys, multidisciplinary conferences, and working groups, following a method similar to that used by the Society of British Neurological Surgeons. The standards cover seven topics relating to all aspects of service delivery, with standards within each objective. Each standard has been designated a priority level (A, B, or C). The standards were piloted using a self-assessment questionnaire, completed by all 20 hospitals of the Eastern region. RESULTS: Full compliance was 36% and a further 30% of standards were partially met across the region, with some areas of service delivery better than others. Seventy eight per cent of level A standards were either fully or partially met. Results were better in the north of the region compared with the south. CONCLUSION: A survey of compliance with the head injury standards indicate that, with their whole systems approach and subject to further refinement, they are a useful method for identifying deficiencies in service provision and monitoring for quality of care both within organisations and regionally.


Subject(s)
Craniocerebral Trauma/therapy , Emergency Service, Hospital/standards , Hospitalization/statistics & numerical data , Delivery of Health Care/standards , England , Humans
6.
Br J Neurosurg ; 20(6): 391-5, 2006 Dec.
Article in English | MEDLINE | ID: mdl-17439091

ABSTRACT

Lumbar canal stenosis (LCS) is a common condition affecting elderly patients for which a significant number undergo surgery. The validity and safety of simple laminectomy in this condition is not fully understood. Furthermore, the presence of pre-existing spondylolisthesis is controversial with respect to the need for additional spinal stabilization. We prospectively studied a consecutive cohort of 100 patients with clinical and radiological LCS under the care of a single spinal surgeon. Outcome measures (SF-36, visual analogue scores for back and leg symptoms, and the Roland/Morris back pain scores) were assessed preoperatively, 3 months postsurgery and at long-term (median 2 years) follow-up. We have shown a significant improvement in outcome sustained in the long-term with minimal morbidity. Patients with pre-existing spondylolisthesis accounted for 23% of the cohort and, having received identical treatment, showed no significant difference in outcome compared with patients with normal alignment.


Subject(s)
Laminectomy , Lumbar Vertebrae/surgery , Spinal Stenosis/surgery , Spondylolisthesis/surgery , Aged , Cohort Studies , Female , Humans , Low Back Pain/diagnosis , Male , Middle Aged , Pain Measurement , Prospective Studies
7.
Br J Neurosurg ; 19(6): 469-74, 2005 Dec.
Article in English | MEDLINE | ID: mdl-16574558

ABSTRACT

Most surgeons undertaking anterior cervical discectomy (ACD) introduce a bone graft or cage into the disc space when the decompression is complete. This is done to prevent segmental collapse, preserve cervical spine alignment and to promote fusion. We have conducted a prospective observational cohort study to investigate the relationship between loss of disc height, cervical spine alignment and clinical outcome in 140 patients undergoing ACD without inter-body graft or cage. At a minimum of 12 months after operation changes in disc space height and cervical spine alignment were correlated with clinical outcome measured by SF36, Neck Disability Index, and visual analogue neck and arm pain scores. There was no relationship between loss of disc height and outcome. Loss of the overall cervical lordosis was present in 71 patients and segmental kyphosis was found in 69. Analysis of clinical outcome showed no significant differences between patients with preserved and abnormal cervical alignment. Neither loss of disc height nor disturbance of cervical alignment compromised clinical outcome in the first year following ACD.


Subject(s)
Cervical Vertebrae/surgery , Diskectomy/adverse effects , Spinal Curvatures/etiology , Cohort Studies , Diskectomy/methods , Female , Humans , Intervertebral Disc , Male , Middle Aged , Prospective Studies , Spinal Cord Diseases/surgery , Treatment Outcome
8.
J Neurol Neurosurg Psychiatry ; 75(11): 1620-2, 2004 Nov.
Article in English | MEDLINE | ID: mdl-15489400

ABSTRACT

OBJECTIVE: To determine the risk for late epilepsy (>2 weeks postoperatively) following aneurysmal subarachnoid haemorrhage (SAH) treated by early aneurysm clipping. DESIGN: Subgroup analysis of the East Anglian regional audit of SAH (1994-2000; n = 872) with 12 month follow up. Prophylactic anticonvulsants were not routinely prescribed unless there was a perioperative seizure. SUBJECTS: 472 patients with aneurysmal SAH undergoing surgical clipping of the aneurysm were studied. Patients presenting in WFNS grade V, with space occupying haematomas requiring emergency surgery, or with posterior circulation aneurysms, rebleeds, and surgery after 21 days were excluded. RESULTS: Late epilepsy occurred in 23 patients (4.9%). There was a correlation between the incidence of late epilepsy and both the presenting WFNS grade (p<0.05) (grade 1, 1.4%; grade 2, 3.8%; grade 3, 9.6%; grade 4, 12.5%) and the Glasgow outcome score at discharge (p<0.01) (good recovery, 2.2%; moderate disability, 5.0%; severe disability, 15.5%). There was no relation between the incidence of late epilepsy and sex or the site of the aneurysm. CONCLUSIONS: The low incidence of late epilepsy following open surgery for aneurysmal SAH supports the withholding of prophylactic anticonvulsants. Patients with poor WFNS grade and poor recovery after surgery are at increased risk and should be closely monitored.


Subject(s)
Craniotomy , Epilepsy/etiology , Intracranial Aneurysm/surgery , Postoperative Complications/etiology , Subarachnoid Hemorrhage/surgery , Adolescent , Adult , Aged , Aged, 80 and over , Anticonvulsants/administration & dosage , Epilepsy/prevention & control , Female , Follow-Up Studies , Glasgow Outcome Scale , Humans , Male , Medical Audit , Middle Aged , Postoperative Complications/prevention & control , Premedication , Risk , United Kingdom
9.
J R Soc Med ; 97(8): 384-9, 2004 Aug.
Article in English | MEDLINE | ID: mdl-15286191

ABSTRACT

Several reports have pointed to the unevenness in the UK of services for rehabilitation after head injury. A study was conducted in the Eastern Region of England to define the key stages in recovery and rehabilitation, by an iterative process of questionnaire, interview and consensus conference. Findings were translated into a draft set of maps showing current availability of services which were revised after feedback. Working groups then developed a set of definitions and classification codes for each stage of rehabilitation which were likewise disseminated for feedback. The maps were then redrafted to correspond with the definitions together with a flowchart of potential head injury rehabilitation services. The definitions were piloted at a regional neurosurgery unit and a rehabilitation hospital. Core services for neurorehabilitation region-wide were found to be variable and uncoordinated with fragmented and inequitable allocation of resources. The definitions and mapping system that emerged from this study should facilitate the design of care pathways for patients and identify gaps in the services.


Subject(s)
Craniocerebral Trauma/rehabilitation , Health Resources/supply & distribution , England , Geography , Health Care Surveys , Humans , Pilot Projects , Rehabilitation Centers/supply & distribution
10.
J Neurol Neurosurg Psychiatry ; 72(4): 480-4, 2002 Apr.
Article in English | MEDLINE | ID: mdl-11909907

ABSTRACT

OBJECTIVES: The debate on the timing of aneurysm surgery after subarachnoid haemorrhage (SAH) pivots on the balance of the temporal risk for fatal rebleeding versus the risk of surgical morbidity when operating early on an acutely injured brain. By following a strict management protocol for SAH, the hypothesis has been tested that in the modern arena of treatment for aneurysmal SAH the timing of surgery to secure supratentorial aneurysms does not affect surgical outcome. METHODS: Over a 6 year period, patients admitted with a diagnosis of SAH to a regional neurosurgical unit have been prospectively studied. All have been on a management protocol in which early transfer and resuscitation has been followed regardless of age and clinical condition. Angiographic investigation and surgery have been pursued in those who have been able to at least flex to pain. A total of 1168 patients (60.7% female, mean age 54.3) with proved SAH were received on median day 1 (86.4% arrived within 3 days) of the ictus. Of these, 784 (67.1%) showed aneurysms on angiography and were prepared for surgery. Those who received surgery for a supratentorial aneurysm within 21 days of the ictus were included in the final analysis (n=550). Patients with an initial negative angiogram, with posterior circulation aneurysms, or aneurysms treated by endovascular means, with aneurysms requiring emergency surgery for space occupying haematomas, with aneurysms which re-bled before surgery, and those who received very late surgery (after 21 days from ictus) were excluded. Surgical outcomes at hospital discharge and after 6 months were assessed using the Glasgow outcome score (GOS). Discharge destination and duration of stay in a neurosurgical ward were also documented. The influence of the timing of surgery (early group day 1-3 postictus, intermediate group day 4-10, or late group day 11-21) was analysed prospectively. RESULTS: 60.2% of cases fell into the early surgery group, 32.4% into the intermediate group, and 7.5% into the late operated group. Late surgery was due to delays in diagnosis, transfer, and logistic factors, but not clinical decision. The demographic characteristics, site of aneurysm, and clinical condition of the patients at the time of initial medical assessment were balanced in the three surgical timing groups. There was no significant difference in GOS between the surgical timing groups at 6 months (favourable GOS score 4 and 5: 83.2%, 80.5%, and 83.8% respectively; p=0.47, Kruskal-Wallis test). Outcome was favourable in 84% of patients under 65 years, and 70% in those over 65. The discharge destinations (home, referring hospital, nursing home, rehabilitation centre) showed no significant difference between surgical timing groups. There was no significant difference in mean time to discharge after admission to this hospital from the referring hospital (16.2, 16.2, and 14.6 days for early, intermediate, and late groups respectively; p=0.789, Analysis of variance (ANOVA)). As a result, there was reduction in the mean duration of total hospital inpatient stay in favour of the earliest operated patients (mean time 18.1, 22.0, and 28.3 days respectively; p=0.001. ANOVA showed that besides age, the only determinant of surgical outcome and duration of stay was presenting clinical grade (p<0.0005). CONCLUSION: The current management of patients presenting with SAH from anterior circulation aneurysms allows early surgery to be followed safely regardless of age. The only independent variables affecting outcome are age and clinical grade at presentation. The timing of surgery did not significantly affect surgical outcome, promoting a policy for early surgery that avoids the known risks of rebleeding and reduces inpatient stay.


Subject(s)
Aneurysm, Ruptured/complications , Cerebral Revascularization , Intracranial Aneurysm/complications , Postoperative Complications , Subarachnoid Hemorrhage/surgery , Adolescent , Adult , Age Factors , Aged , Aged, 80 and over , Female , Humans , Male , Middle Aged , Prospective Studies , Risk Factors , Sex Factors , Subarachnoid Hemorrhage/etiology , Time Factors , Treatment Outcome
11.
Br J Neurosurg ; 16(6): 545-9, 2002 Dec.
Article in English | MEDLINE | ID: mdl-12617234

ABSTRACT

The objective was to establish the role of the Short Form 36 (SF 36) as an objective measure of clinical outcome in cervical spondylotic myelopathy (CSM), and took the form of a prospective observational study. Seventy patients with symptomatic CSM were treated by surgical decompression. Health status was measured pre- and 3 months postoperation using objective, validated patient completed measures. These were the SF 36, neck disability index, myelopathy disability index and analogue scores for neck pain and arm symptoms. SF 36 scores were compared with age matched control data. Twelve-month postoperative data are available in a proportion of the cohort. CSM patients have lower preoperative SF 36 scores than age-matched population controls. Comparing pre- and postoperative SF36 scores for the physical functioning domain 64% of patients improve, 23% show no change and 14% of patients continue to deteriorate (Wilcoxon P< 0.0001). These changes are replicated in other domains of the SF36 and by the other measures of outcome. The SF36 is responsive, valid, and practical. Its use for determining outcome in the surgical treatment of CSM is recommended.


Subject(s)
Cervical Vertebrae/surgery , Spinal Cord Diseases/surgery , Spinal Osteophytosis/surgery , Adult , Aged , Decompression, Surgical/methods , Emotions , Humans , Male , Middle Aged , Pain Measurement , Prospective Studies , Recovery of Function , Spinal Cord Diseases/physiopathology , Spinal Cord Diseases/psychology , Spinal Osteophytosis/physiopathology , Spinal Osteophytosis/psychology , Surveys and Questionnaires , Treatment Outcome
12.
Br J Neurosurg ; 15(4): 319-23, 2001 Aug.
Article in English | MEDLINE | ID: mdl-11599447

ABSTRACT

Most surgeons undertaking anterior cervical discectomy (ACD) introduce a bone graft or cage into the disc space when the decompression is complete to prevent segmental collapse and preserve cervical spine alignment. We have conducted a prospective observational cohort study to investigate the relationship between cervical spine alignment and clinical outcome in 55 patients undergoing ACD without interbody graft or cage. At 12 months, the overall alignment of the cervical spine and the presence of segmental kyphosis at the operated level were correlated with clinical outcome measured by SF 36, Neck Disability Index and visual analogue neck pain score. Loss of the overall cervical lordosis was present in 30 patients and segmental kyphosis was found in 18. Analysis of clinical outcome showed no statistical differences between patients with preserved and abnormal cervical and segmental alignment. Disturbance of cervical and segmental alignment is common in patients following cervical discectomy, but does not appear to compromise clinical outcome at 12 months.


Subject(s)
Cervical Vertebrae/surgery , Diskectomy/adverse effects , Spinal Curvatures/etiology , Adult , Diskectomy/methods , Female , Follow-Up Studies , Humans , Kyphosis/diagnostic imaging , Kyphosis/etiology , Male , Middle Aged , Neck Pain/etiology , Pain Measurement , Prospective Studies , Radiography , Spinal Curvatures/diagnostic imaging , Treatment Outcome
13.
Emerg Med J ; 18(5): 358-65, 2001 Sep.
Article in English | MEDLINE | ID: mdl-11559606

ABSTRACT

OBJECTIVES: The Royal College of Surgeons (RCS) Report on the management of patients with head injuries under the chairmanship of Professor Galasko, published in June 1999, made important recommendations that will have a profound effect on the organisation of management of head injuries and major implications for resources. The Eastern Region carried out an audit study to determine the provision of current services available, to assess the shortfall and likely resource implications for the implementation of the report and hence lay the foundations for a strategic plan for change across the region. METHODOLOGY: A series of interviews with all 20 accident and emergency (A&E) departments across the Eastern Region and the two regional neuroscience units (RNU) was undertaken. The results of the survey and the implications of the implementation were fed back to and discussed at a multidisciplinary regional seminar. RESULTS: There is considerable variation and major deficiencies in the service provision currently available for the management of head injuries in the Eastern Region. There are major deficiencies in A&E resources, care of moderate head injuries and rehabilitation and follow up of patients. There is a significant shortfall in resources for the implementation of the recommendations. CONCLUSION: There are major deficiencies in the overall management of head injuries. Although the RCS Galasko Report recommendations were agreed to be very desirable, they cannot be implemented without a large increase in resources in terms of funding, staffing and training.


Subject(s)
Craniocerebral Trauma/therapy , Emergency Service, Hospital/statistics & numerical data , Practice Guidelines as Topic , Practice Patterns, Physicians'/statistics & numerical data , Craniocerebral Trauma/epidemiology , England/epidemiology , Guideline Adherence , Humans , Interviews as Topic , Medical Audit , Quality of Health Care
14.
Acta Neurochir Suppl ; 76: 483-4, 2000.
Article in English | MEDLINE | ID: mdl-11450074

ABSTRACT

Previously, using transcranial Doppler ultrasonography, we investigated whether the hemodynamic response to spontaneous variations in cerebral perfusion pressure (CPP) provides reliable information about cerebral autoregulatory reserve. In the present study we have verified this method in 166 patients after head trauma. Waveforms of intracranial pressure (ICP), arterial pressure and transcranial Doppler flow velocity (FV) were captured daily over 0.5-2.0 hour periods. Time-averaged mean flow velocity (FV) and CPP were resolved. The correlation coefficient indices between FV and CPP (Mx) were calculated over 3 minutes epochs, and averaged for each investigation. An index of CBF (flow velocity diastolic to mean ratio) was calculated independently for each investigation. Mx depended on CPP (p < 0.0001) increasing to positive values when CPP decreased below 60 mm Hg. This threshold coincided with an averaged breakpoint for autoregulation, expressed by the index of CBF. Mx depended on outcome following head injury stronger than the Glasgow Coma Score on admission (ANOVA, F values 18 and 15 respectively; N = 166). In patients who died, cerebral autoregulation was disturbed during the first two days following injury. These results indicate an important role for the continuous monitoring of autoregulation following head trauma.


Subject(s)
Brain Edema/diagnosis , Brain Injuries/diagnosis , Brain/blood supply , Homeostasis/physiology , Ultrasonography, Doppler, Transcranial , Vascular Resistance/physiology , Blood Flow Velocity/physiology , Blood Pressure/physiology , Brain Edema/physiopathology , Brain Injuries/physiopathology , Glasgow Outcome Scale , Humans , Intracranial Pressure/physiology , Prognosis
16.
Br J Neurosurg ; 12(1): 37-40, 1998 Feb.
Article in English | MEDLINE | ID: mdl-11013646

ABSTRACT

The major causes of death following subarachnoid haemorrhage are the effects of the initial bleed, aneurysmal rebleeding and delayed cerebral ischaemia. Although in many cases the causes are unavoidable, in others they are potentially preventable. By conducting a Regional Audit of patients who have died from subarachnoid haemorrhage, we have attempted to quantify these concerns. The medical records and CT scans of 200 patients who died from subarachnoid haemorrhage in hospitals in the East Anglian Region over a 5-year period were analysed, with particular regard to the identification of potentially avoidable factors, including radiologically confirmed rebleeding, marked hydrocephalus, and poor fluid and electrolyte resuscitation. Thirty-three patients presented with World Federation of Neurosurgical Societies (WFNS) Grade V with fixed pupils. These patients were deemed unsalvageable. Of the remainder, 106 were good grade (WFNS I-III) at initial presentation, 77 (73%) of whom died as a result of rebleeding (mean 10.4 days post-bleed) indicating delays in transfer and definitive treatment. Of the 61 poor grade patients (WFNS IV and V with reactive pupils) marked hydrocephalus occurred in 15 (25%) and poor resuscitation in 37 (61%). These were considered contributing factors to their poor clinical condition. Rebleeding was the main cause of death in the good grade patients, and correctable factors were identified which are known to contribute to a poor clinical condition in poor grade patients. The need for more rapid and active clinical intervention is indicated.


Subject(s)
Cause of Death , Subarachnoid Hemorrhage/mortality , Adolescent , Adult , Aged , Aged, 80 and over , Child , Child, Preschool , England , Female , Glasgow Coma Scale , Humans , Hydrocephalus/mortality , Hydrocephalus/surgery , Infant , Male , Middle Aged , Prognosis , Recurrence , Resuscitation/mortality , Risk Factors , Subarachnoid Hemorrhage/surgery , Survival Analysis , Tomography, X-Ray Computed
17.
Anaesthesia ; 51(6): 571-4, 1996 Jun.
Article in English | MEDLINE | ID: mdl-8694212

ABSTRACT

Surveys conducted in the United Kingdom over the last few years have revealed decreased job satisfaction and increased anxiety and depression in both hospital specialists and general practitioners. Anaesthesia is perceived to be a stressful specialty and there is evidence, albeit patchy, that certain stress-associated conditions are more common in anaesthetists. The 'middle years' seem to be a danger period. The analogy between the work of anaesthetists and airline pilots is often drawn and the principles underlying the assessment and maintenance of pilot competence could be adopted in anaesthesia. While outcome studies are numerous much less attention has been paid to the structure and process of anaesthetic practice. Models for studying these aspects have been developed for investigating stress in general practitioners and doctors in training. Even minor degrees of professional impairment may place patients at risk and an investigation into the effects of the specialty on those who practise it is justified.


Subject(s)
Anesthesiology , Medical Staff, Hospital/psychology , Occupational Diseases/psychology , Stress, Psychological/complications , Anesthesiology/statistics & numerical data , Humans , Job Satisfaction , Occupational Diseases/mortality , Stress, Psychological/mortality , Substance-Related Disorders/psychology
19.
Acta Anaesthesiol Belg ; 42(2): 107-12, 1991.
Article in English | MEDLINE | ID: mdl-1681665

ABSTRACT

1. The effects of two competitive neuromuscular blocking agents, pancuronium and vecuronium, on plasma levels of immunoglobulins, IgG, IgM and IgE, were studied and compared, using the ELISA assay, in patients undergoing minor gynaecological surgery. 2. The results showed that neither pancuronium (0.1 mg/kg) nor vecuronium (0.1 mg/kg) had any significant effect on IgG, IgM and IgE levels in these patients. However, the underlying trend was that both pancuronium and vecuronium slightly increased the IgG and IgM levels, (by 19.5%, 22.1%, of control IgG, and by 17.3%, 28.8% of control IgM, respectively), with vecuronium being more effective than pancuronium). In addition, pancuronium, but not vecuronium, also slightly increased the IgE levels (by 5.9% of control IgE). Vecuronium, on the other hand, slightly decreased the IgE level (by 4.9% of control IgE). However, these increases or decreases were not statistically significant. 3. The significance of the present results are discussed in relation to changes in immunoglobulins and adverse effects induced by drugs, such as muscle relaxants.


Subject(s)
Immunoglobulins/drug effects , Pancuronium/pharmacology , Vecuronium Bromide/pharmacology , Adult , Aged , Female , Humans , Immunoglobulin E/drug effects , Immunoglobulin G/drug effects , Immunoglobulin M/drug effects , Middle Aged , Random Allocation
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