1.
Inflamm Res
; 51 Suppl 1: S65-6, 2002 Apr.
Article
in English
| MEDLINE
| ID: mdl-12013414
Subject(s)
Histamine H1 Antagonists/toxicity , Joint Diseases/chemically induced , Joints/embryology , Abnormalities, Drug-Induced/pathology , Animals , Bone and Bones/embryology , Bone and Bones/pathology , Cleft Palate/chemically induced , Cleft Palate/pathology , Female , Joint Diseases/pathology , Joints/pathology , Pregnancy , Rats
2.
Inflamm Res
; 48 Suppl 1: S67-8, 1999 Apr.
Article
in English
| MEDLINE
| ID: mdl-10350167
Subject(s)
Histamine Agonists/pharmacology , Histamine Antagonists/pharmacology , Receptors, Histamine H2/drug effects , Receptors, Histamine H2/physiology , Seizures/physiopathology , Acoustic Stimulation , Animals , Anticonvulsants/pharmacology , Benzothiazoles , Convulsants/administration & dosage , Dimaprit/administration & dosage , Dimaprit/pharmacology , Female , Male , Mice , Mice, Inbred DBA , Pentylenetetrazole/administration & dosage , Phenoxypropanolamines , Piperidines/pharmacology , Seizures/etiology , Thiazoles/pharmacology
3.
Inflamm Res
; 46 Suppl 1: S53-4, 1997 Mar.
Article
in English
| MEDLINE
| ID: mdl-9098762
4.
Inflamm Res
; 46 Suppl 1: S55-6, 1997 Mar.
Article
in English
| MEDLINE
| ID: mdl-9098763
Subject(s)
Embryonic and Fetal Development/drug effects , Histamine H2 Antagonists/toxicity , Animals , Cimetidine/pharmacology , Cimetidine/toxicity , Female , Growth/drug effects , Histamine H2 Antagonists/pharmacology , Pregnancy , Ranitidine/pharmacology , Ranitidine/toxicity , Rats , Reflex/drug effects , Reflex, Startle/drug effects
5.
6.
7.
Inflamm Res
; 44 Suppl 1: S74-5, 1995 Apr.
Article
in English
| MEDLINE
| ID: mdl-8521011
Subject(s)
Behavior, Animal/drug effects , Bone Development/drug effects , Bone and Bones/drug effects , Histamine H1 Antagonists/pharmacology , Prenatal Exposure Delayed Effects , Analysis of Variance , Animals , Bone and Bones/embryology , Cell Division/drug effects , Embryonic and Fetal Development/drug effects , Female , Pregnancy , Rats
8.
Agents Actions
; 41 Spec No: C68-9, 1994 Jun.
Article
in English
| MEDLINE
| ID: mdl-7976808
ABSTRACT
Central histaminergic modulation of H1 rather than H2-receptors has been shown to modify epileptic activity. Compounds acting on the HIC- and H3-receptors were tested against chemically-induced seizures in mice. Compounds antagonising the microsomal and nuclear intracellular receptors (HIC) only modified seizures at doses where toxicity was observed. Antagonists of the histamine H3-receptor (thioperamide and burimamide) only potentiated the severity of clonic convulsions induced by picrotoxin, while impromidine (i.c.v.), an antagonist with H2-agonist activity, inhibited leptazol-induced seizures. The H3-agonist, (R)alpha-methylhistamine, potentiated chemically-induced seizures, but at lower doses there was slight inhibition.
