Tuberous sclerosis. CT findings versus clinical state.

Even though tuberous sclerosis has been known and diagnosed for almost a century, it is the last decade which has contributed with the largest amount of information of this entity, especially intracranially due to the widespread use of CT investigations. Like any other type of diagnostic radiology, CT will not always correlate to clinics as expected, which we would like to demonstrate in these two case-stories.

Uremia in a family with tuberous sclerosis.

Tuberous sclerosis (TS) is characterized by the triade of epilepsy, mental retardation, and adenoma sebaceum. Although the kidneys are affected in 40-80% of the patients uremia is a rare finding. We here describe a family with TS, where uremia was a major feature of the disease, causing the death of 2 family members and requiring active replacement therapy in a third person, who now 11 years after renal transplantation, has normal renal function.

Preoperative radiographically guided wire marking of nonpalpable breast lesions.

In 37 women with possibly malignant lesions detected at radiography of the breast, 42 excisional biopsies were performed using preoperative guide wire marking at radiography. The wire transfixed or missed the lesion by less than one cm in 95 per cent of the cases, and in all but three cases a precise localization was obtained with only one wire. Full removal of the lesion was obtained at the first excision in 40 procedures and a second excision was necessary in only two patients. Minor wound complications occurred in two patients. The malignancy rate was 13.5 per cent and metastatic lymph node involvement was not observed in any of the patients. The localization method described is easy to perform and highly recommendable.