Fast myocardial T1ρ mapping in mice using k-space weighted image contrast and a Bloch simulation-optimized radial sampling pattern.

PURPOSE: T1ρ dispersion quantification can potentially be used as a cardiac magnetic resonance index for sensitive detection of myocardial fibrosis without the need of contrast agents. However, dispersion quantification is still a major challenge, because T1ρ mapping for different spin lock amplitudes is a very time consuming process. This study aims to develop a fast and accurate T1ρ mapping sequence, which paves the way to cardiac T1ρ dispersion quantification within the limited measurement time of an in vivo study in small animals. METHODS: A radial spin lock sequence was developed using a Bloch simulation-optimized sampling pattern and a view-sharing method for image reconstruction. For validation, phantom measurements with a conventional sampling pattern and a gold standard sequence were compared to examine T1ρ quantification accuracy. The in vivo validation of T1ρ mapping was performed in N = 10 mice and in a reproduction study in a single animal, in which ten maps were acquired in direct succession. Finally, the feasibility of myocardial dispersion quantification was tested in one animal. RESULTS: The Bloch simulation-based sampling shows considerably higher image quality as well as improved T1ρ quantification accuracy (+ 56%) and precision (+ 49%) compared to conventional sampling. Compared to the gold standard sequence, a mean deviation of - 0.46 ± 1.84% was observed. The in vivo measurements proved high reproducibility of myocardial T1ρ mapping. The mean T1ρ in the left ventricle was 39.5 ± 1.2 ms for different animals and the maximum deviation was 2.1% in the successive measurements. The myocardial T1ρ dispersion slope, which was measured for the first time in one animal, could be determined to be 4.76 ± 0.23 ms/kHz. CONCLUSION: This new and fast T1ρ quantification technique enables high-resolution myocardial T1ρ mapping and even dispersion quantification within the limited time of an in vivo study and could, therefore, be a reliable tool for improved tissue characterization.

Balanced spin-lock preparation for B1 -insensitive and B0 -insensitive quantification of the rotating frame relaxation time T1ρ.

PURPOSE: Accurate and artifact-free T1ρ quantification is still a major challenge due to a susceptibility of the spin-locking module to B0 and/or B1 field inhomogeneities. In this study, we present a novel spin-lock preparation module (B-SL) that enables an almost full compensation of both types of inhomogeneities. METHODS: The new B-SL module contains a second 180° refocusing pulse to compensate each pulse in the preparation block by a corresponding pulse with opposite phase. For evaluation and validation of B-SL, extensive simulations as well as phantom measurements were performed. Furthermore, the new module was compared to three common established compensation methods. RESULTS: Both simulations and measurements demonstrate a much lower susceptibility to artifacts for the B-SL module, therefore providing an improved accuracy in T1ρ quantification. In the presence of field inhomogeneities, measurements revealed an increased banding compensation by 79% compared with the frequently used composite module. The goodness of the mono-exponential T1ρ fitting procedure was improved by 58%. CONCLUSION: The B-SL preparation enables the generation of accurate relaxation maps with significantly reduced artifacts, even in the case of large field imperfections. Therefore, the B-SL module is suggested to be highly beneficial for in vivo T1ρ quantification.