ABSTRACT
A 18 years male had congenital hypoplasia of the right external iliac artery and thrombosis of its narrowest part. Congenital megacolon, anal atresia and hyposomical nanism were also present. Surgical intervention was indicated because he was developing arterial insufficiency and muscular hypotrophy of the right leg. A bypass was performed with a reversed autogenous vein between the common iliac artery and the common femoral artery.
Subject(s)
Iliac Artery/abnormalities , Thrombosis/etiology , Abnormalities, Multiple/pathology , Adolescent , Blood Vessel Prosthesis , Femoral Artery/surgery , Humans , Leg/blood supply , Male , Thrombosis/surgeryABSTRACT
A method has been developed for the removal, preservation and electrophysiological study 'in vitro' of sympathetic lumbar chains (L1-L3) from subjects undergoing lumbar ganglionectomy in the treatment of peripheral vascular diseases. Extracellular recordings from interganglionic trunks, and intracellular recordings from single sympathetic neurons, were performed. The extracellular experiments substantiated the concept, hitherto deduced from animal experiments, that the preganglionic fibres in the sympathetic lumbar chain are mainly of a descending nature. In fact, stimulation of the interganglionic trunk cranial to ganglia is always much more effective in driving ganglion neurons to fire than stimulation of the interganglionic trunk caudal to ganglia. The intracellular experiments produced a good definition of the main electrical characteristics of human sympathetic neurons. The results can be summarized as follows: the resting membrane potential ranged from 50 to 75 mV (63.4 +/- 9.2 mV; 21 neurons); action potential amplitude from 62 to 93 mV (74.3 +/- 8.1 mV; 27 neurons); membrane input resistance was 42.3 +/- 12.6 m omega (8 neurons) and total membrane capacitance 83.7 +/- 15.3 pF (8 neurons).
Subject(s)
Autonomic Fibers, Preganglionic/physiology , Ganglia, Sympathetic/physiology , Action Potentials , Aged , Aged, 80 and over , Electric Stimulation , Female , Humans , In Vitro Techniques , Male , Membrane Potentials , Middle AgedABSTRACT
The effects of the following vasoactive drugs: Bencyclan fumarate, Cetiedil citrate, Cinepazide maleate, Dihydroergocristine methane sulphonate, Nafthydrofuril acid oxalate, Papaverine hydrochloride, Piribedil monomethane sulphonate, Raubasine, Thymoxamine hydrochloride and Xanthinol nicotinate, in concentrations ranging between 0.001 - 2 mM, were tested on the compound action potentials led off from human isolated sympathetic ganglions. The experiments, carried out on 50 isolated lumbar ganglion preparations removed from 23 subjects with arteriopathy of the limbs, indicated that all the drugs are able to impair the synaptic transmission, although at different concentrations. These findings are in favour of the hypothesis that the vasodilatatory effects observed after therapeutic treatment of patients with vasoactive drugs are partially produced by the vasodilatation following the depression of the sympathetic nervous transmission.
