ABSTRACT
BACKGROUND: The incidence of childhood obesity has received a lot of attention lately, especially in the United States. The increased prevalence of pediatric obesity and its association with comorbidities has piqued the attention of more scientists in the epidemic's patterns. Our research examined the National (Nationwide) Inpatient Sample (NIS) data set for hospitalized persons aged 18 years or younger with primary or secondary obesity between 2016 and 2019 to investigate the prevalence, risk factors, and related diseases. METHODS: We retrospectively examined individuals with primary or secondary obesity from 2016 to 2019 using the NIS database. To extract the weighted samples, we utilized the International Classification of Diseases (ICD)-10 diagnostic codes E66, E660, E6601, E6609, E662, E668, and E669. Individuals with drug-related obesity or obesity caused by a recognized pathologic disease unrelated to high-calorie intake were excluded. First, we queried the total population, then separated them by age category and picked our population of interest, i.e., those aged 18 and under. The NIS is a deidentified database available to the public. It collects data on around 8 million hospitalizations annually, accounting for roughly 20% of all admissions in the United States. Results: The findings show that between 2016 and 2019, prevalence rates of childhood obesity were still on the rise and plateaued in 2019. There were 28,484,087 study subjects in this weighted sample between 2016 and 2019. Of these, 13.9% (3,946,889) were diagnosed with obesity. The sample population for those 18 years of age or under was 62,669 (1.5%) children with obesity with a mean age of 14 (SD = 4). Also, there was a 64.2% female preponderance. The obtained yearly showed a steady and significant rise from 2016 to 2018 (24% vs. 26%), with a slight decline in 2019 (25%; p < 0.001). Even though the white population had the highest overall prevalence of childhood obesity (40.9%), the Hispanic and black people had a higher prevalence per population, with a 0.5% and 0.33% prevalence, respectively, compared to 0.14% in the white population (p < 0.0001). When geographical regions were considered, south had the highest rate (36.40%), followed by the west (24.71%) and the midwest (23.56%). The analysis also showed that people with lower median household income (0-25th percentile) had the highest rate of childhood obesity (38.17%) compared to higher-income earners (13.19%). CONCLUSION: In our finding, obesity in the pediatric population is still increasing, continuing on its previously recorded trajectory. Various recommendations from health policymakers have bolstered efforts to tackle this escalating pandemic. However, additional information on the compliance, use, and adherence to these policies by healthcare professionals and members of the public, as well as the consequence of utilization or compliance to these guidelines, is needed. Nevertheless, given the continuous growth of childhood obesity, despite the avalanche of these recommendations, the issue of compliance arises, or other essential risk factors might have been overlooked. Additional studies may be needed to unmask this looming phenomenon.
ABSTRACT
High-fat diets have been identified as a major cause of obesity and a potential risk factor for breast cancer. Fat tissue, also known as adipose tissue, produces an excess of estrogen, which has been linked to an increased risk of breast cancer. Determining the impact of HFDs in the development and progression of breast cancer is essential, as it will enable us to identify the role of dietary modification in preventing and managing the disease. The impact of a high-fat diet (HFD) on the development of breast cancer in humans has yet to be fully explained, as very few human studies are available to effectively analyze the effect fatty food has on breast cancer development. This meta-analysis, therefore, seeks to determine the strength of association, if any, between HFD and an increased risk of breast cancer development. This research will help inform good eating habits, potentially reducing the disease's incidence and outcome. This meta-analysis examined eight (8) papers from various nations examining the effect of a high-fat diet as a risk factor for breast cancer development between 2010 and 2020. The study employed the multivariable-adjusted hazard ratio (H.R.), odds ratio (OR), or relative risk (R.R.) from the studies. Breast cancer cases were histologically and radiologically confirmed in the studies evaluated, and validated food frequency questionnaires were used to assess their dietary patterns. This metanalysis study found a substantial link between a high-fat diet and an increased risk of breast cancer, with statistically significant results (I2 = 93.38%, p0.05). Changes in dietary fat consumption may thus help mitigate some of the unfavorable consequences of breast cancer and survival. Even if further research is needed to support this assertion, the findings are compelling enough to advocate for low-fat, healthy diets to avoid breast cancer.
