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1.
Indian Dermatol Online J ; 12(1): 203-205, 2021.
Article in English | MEDLINE | ID: mdl-33768060
2.
Indian Dermatol Online J ; 10(4): 481-485, 2019.
Article in English | MEDLINE | ID: mdl-31334080

ABSTRACT

The injudicious use of antifungals, indiscriminate use of corticosteroids for instant relief, persistence of predisposing factors like sweat retention and uncontrolled diabetes, and emerging resistance to antifungals across the globe have rendered the management of an erstwhile simple infection, the superficial cutaneous mycoses highly complicated and tricky. Ciclopirox is an old yet efficacious, versatile, and safe topical antifungal of the hydroxypyridone family. Despite its numerous beneficial properties over the majority of other topical antifungals, it remains underutilized.

3.
Clin Exp Dermatol ; 38(3): 285-8, 2013 Apr.
Article in English | MEDLINE | ID: mdl-23517359

ABSTRACT

We report a patient with plexiform neurofibroma, which is pathognomonic for neurofibromatosis type 1 (NF1) affecting the upper parietal region of the scalp. Cerebellar hamartoma was present, a finding that, to our knowledge, has not been reported previously. We highlight the role of histopathology, ultrasonography, colour Doppler imaging and magnetic resonance imaging, in addition to the seven existing criteria, for the diagnosis of NF1.


Subject(s)
Cerebellar Diseases/diagnosis , Hamartoma/diagnosis , Neurofibroma, Plexiform/diagnosis , Scalp Dermatoses/diagnosis , Adult , Cerebellar Diseases/pathology , Echocardiography, Doppler, Color , Female , Hamartoma/pathology , Humans , Magnetic Resonance Imaging , Neurofibroma, Plexiform/pathology , Scalp Dermatoses/pathology , Young Adult
5.
J Eur Acad Dermatol Venereol ; 25(6): 625-36, 2011 Jun.
Article in English | MEDLINE | ID: mdl-21108666

ABSTRACT

Juvenile insulin-dependent diabetes mellitus type 1 (IDDM) is a well-recognized worldwide entity, the significance of which has increased because of its recent upsurging trends, warranting attention on variety of its clinical expressions, in particular, pertaining to skin, an aspect seldom taken cognizance of. Hence an endeavour to recap the related dermatoses, such as limited joint mobility syndrome including sclerodermoid (scleroderma-like) changes, xerosis, necrobiosis lipoidica diabeticorum, granuloma annulare, diabetic foot syndrome, has been made. Complexities relating to the recently explored issues of atopic dermatitis and drug hypersensitivity syndrome have also been covered adequately. In addition, the current concepts of the physiopathology of type 1 diabetes-related dermatoses are briefly recapitulated for clarity.


Subject(s)
Diabetes Mellitus, Type 1/complications , Skin Diseases/etiology , Skin Diseases/physiopathology , Humans
7.
J Eur Acad Dermatol Venereol ; 23(5): 556-60, 2009 May.
Article in English | MEDLINE | ID: mdl-19143903

ABSTRACT

BACKGROUND: In view of the potentially serious side-effects of standard isotretinoin (0.5-1.0 mg/kg per day) therapy for acne, we studied the safety and efficacy of low-fixed dose isotretinoin plus topical 1%clindamycin gel in the treatment of moderate grade of acne. METHODS: In this prospective, non-comparative study, 320 adult patients, with moderately severe acne were enrolled and treated with fixed-dose isotretinoin at 20 mg every alternate day (approximately 0.15 mg/kg/day to 0.28 mg/kg/day) for 6 months along with topical clindamycin gel. All female patients were assessed for polycystic ovarian disease. Patients were followed up for 6 months. RESULTS: A total of 305 patients completed the study. Overall, patients received a mean of 38.4 mg/kg cumulative dose of isotretinoin, and very good results were observed in 208 (68.20%), while good response was seen in 59 (19.34%) of patients. Failure of the treatment occurred in 38 (12.46%), while relapses occurred in 50 (16.39%) of patients. Relapses were commoner in females, and 37 of 43 (86.04%) patients had polycystic ovarian disease. Though mild chelitis (91%) and xerosis (43%) were common, laboratory abnormalities in the form of elevated hepatic enzymes (5%) and elevated serum lipids (6%) were rare. CONCLUSION: Six months of treatment with fixed-dose, alternate-day isotretinoin (20 mg) plus topical 1%clindamycin gel was found to be effective in the treatment of moderate acne in adult patients, with a low incidence of side-effects.


Subject(s)
Acne Vulgaris/drug therapy , Anti-Bacterial Agents/administration & dosage , Clindamycin/administration & dosage , Dermatologic Agents/administration & dosage , Isotretinoin/administration & dosage , Administration, Topical , Adolescent , Adult , Anti-Bacterial Agents/therapeutic use , Child , Clindamycin/therapeutic use , Dermatologic Agents/therapeutic use , Dose-Response Relationship, Drug , Drug Administration Schedule , Female , Humans , Isotretinoin/therapeutic use , Male , Prospective Studies , Treatment Outcome , Young Adult
11.
J Eur Acad Dermatol Venereol ; 21(4): 473-9, 2007 Apr.
Article in English | MEDLINE | ID: mdl-17373973

ABSTRACT

BACKGROUND: Androgenetic alopecia (AGA) has received scant attention, despite it being a common entity that may result in significant psychosocial morbidity. There are some patients who do not fit into any of the proposed types. Moreover, there have been no published studies of pattern and prevalence of AGA in males in an Indian context. Hence, the present study was an attempt to classify AGA in males with the aim of producing a simple, effective and easily reproducible classification. METHODS: In total, 150 male patients were clinically diagnosed as AGA. After obtaining informed consent from all patients, a detailed history/examination was carried out, including a hair pull test, a trichogram investigation and a biopsy. Classification of AGA was subsequently attempted across Norwood guidelines. RESULTS: A gradual shift in the type of AGA from the earlier types (II and III) to more severe types (VI) with increasing age was significant. Twenty-seven patients did not fit into specific patterns according to Hamilton and Norwood classifications. In addition, type 'a' variant was recorded in 20% of patients, clearly indicating limitations of the existing classifications. CONCLUSIONS: It was possible to classify 80% of the AGA, with II (28%) and III (15%) being the most common types of AGA. Twenty-seven patients (18%) could not be classified as a significant finding. There was considerable overlap in types IV, V and VI in the Norwood classification with the 'a' variants further confusing the picture.


Subject(s)
Alopecia/classification , Adolescent , Adult , Age of Onset , Alopecia/genetics , Alopecia/pathology , Disease Progression , Hair/pathology , Hair Preparations , Humans , India , Male , Middle Aged , Scalp/pathology
14.
J Eur Acad Dermatol Venereol ; 20(8): 911-5, 2006 Sep.
Article in English | MEDLINE | ID: mdl-16922936

ABSTRACT

Trichotillomania is an intriguing psychosomatic entity in which there is an irresistible desire to pull out the hair from the scalp, eyelashes, eyebrows and other parts of the body. The process results in an instant release of tension, a sense of relief and security. However, non-scaring alopecia is its clinical presentation. The development of trichobezoar following ingestion of the pulled hair is its salient complication in a few cases. Subsequently, it may cause symptoms pertaining to the gastrointestinal tract culminating in intestinal obstruction, perforation, pancreatitis and obstructive jaundice. The Rapunzel syndrome (trichobezoar) may occur when gastrointestinal obstruction is produced by a rare manifestation of a trichobezoar with a long tail that extends to or beyond the ileocecal valve. In most cases in children, trichotillomania +/- trichobezoar is a habit disorder and thus has a better prognosis. However, in adults the psychopathology is usually deeper and thus entails a poor prognosis. The diagnosis is made after taking a thorough history, noting the clinical features and evaluating a hair-root examination, where telogen hair is (almost) completely lacking, which distinguish trichotillomania from other hair disorders. Treatment modalities vary in childhood and adult varieties. Apart from psychotherapy, the drug treatment involves several agents including selective serotonin reuptake inhibitors (SSRIs) and domipramine. Trichobezoar/Rapunzel syndrome requires surgical intervention.


Subject(s)
Bezoars/complications , Trichotillomania/complications , Adolescent , Adult , Bezoars/surgery , Child , Child, Preschool , Female , Humans , Male , Trichotillomania/diagnosis , Trichotillomania/therapy
16.
Clin Exp Dermatol ; 29(2): 147-9, 2004 Mar.
Article in English | MEDLINE | ID: mdl-14987270

ABSTRACT

An unusual giant combined dermatofibroma is reported in a 34-year-old man who presented with skin-coloured swellings on the medial aspect of the left scapula. The plaque was well defined, reddish-brown and 25-30 cm in diameter. It was also tender and indurated. Several similar smaller lesions (satellites) were present around the plaque. Light microscopy of an incisional biopsy from the main lesion showed architectural features of a deep penetrating type of dermatofibroma, with xanthomatous aggregates, myxoid changes and probable myofibroblastic differentiation. Our case represents an extraordinary example of giant combined dermatofibroma with satellitosis. Despite its benign nature, a wide excision is contemplated because of its unsightly appearance and physical discomfort.


Subject(s)
Histiocytoma, Benign Fibrous/pathology , Neoplasms, Multiple Primary/pathology , Skin Neoplasms/pathology , Adult , Biopsy , Humans , Male , Skin/pathology
18.
J Dermatolog Treat ; 14(1): 30-42, 2003 Jan.
Article in English | MEDLINE | ID: mdl-12745853

ABSTRACT

Ever since the introduction of itraconazole and terbinafine in the management of onychomycosis, there has been a revival of interest in the latter. In order to comprehend the intricate emerging scenario, an endeavor has been made to form a distinct outline in the shape of an overview on several of their facets. The review, therefore, envisages forming and facilitating instant decision-making.


Subject(s)
Antifungal Agents/therapeutic use , Itraconazole/therapeutic use , Naphthalenes/therapeutic use , Onychomycosis/drug therapy , Antifungal Agents/administration & dosage , Antifungal Agents/adverse effects , Drug Administration Schedule , Humans , Itraconazole/administration & dosage , Itraconazole/adverse effects , Naphthalenes/administration & dosage , Naphthalenes/adverse effects , Terbinafine
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