Subject(s)
Hematologic Diseases/surgery , Splenectomy , Adolescent , Adult , Anemia, Hemolytic/surgery , Child , Child, Preschool , Elective Surgical Procedures , Female , Follow-Up Studies , Humans , Male , Purpura, Thrombocytopenic, Idiopathic/surgery , Retrospective Studies , Spherocytosis, Hereditary/surgery , Treatment Outcome , beta-Thalassemia/surgerySubject(s)
Albendazole/therapeutic use , Anthelmintics/therapeutic use , Echinococcosis, Pulmonary/drug therapy , Echinococcosis, Pulmonary/surgery , Adolescent , Child , Child, Preschool , Combined Modality Therapy , Echinococcosis, Pulmonary/diagnostic imaging , Female , Follow-Up Studies , Humans , Male , Postoperative Complications , Radiography , Treatment Outcome , TurkeyABSTRACT
A 2-year-old boy with hemimegalencephaly and Hirschsprung's disease is reported. The unique association of these two entities is considered to be the presence of a common insult or insults that affect the innervation of the bowel and the formation of the cerebral cortex. Short-segment subtype of Hirschsprung's disease may suggest that this effect occurred between the eighth and twelfth weeks of gestation. Although there is a well-known coexistence of Hirschsprung's disease with the malformations that share a common neurocristopathic origin (abnormalities of neural crest cell growth, migration, or differentiation), a few extremely rare cases, as in this case, might reflect the coexistence of Hirschsprung's disease with a cerebral malformation (i.e., hemimegalencephaly) that is a nonneurocristopathic entity by itself.
