ABSTRACT
Background and objective: According to the Global Burden of Diseases, Injuries, and Risk Factors, lower respiratory infections cause more than 2.3 million deaths globally, with a majority occurring in sub-Saharan Africa, including Ethiopia.Community-acquired pneumonia (CAP) is a major contributor to global mortality and morbidity. Understanding the prevalence and common bacterial causes of CAP is crucial for clinicians to accurately diagnose and improve patient satisfaction. The purpose of this systematic review was to report the pooled prevalence and common bacterial etiologies of CAP among adult patients in Ethiopia. Methods: This review was conducted based on the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. A comprehensive search of the published articles between January 2000 and October 2022 was performed using open access electronic databases such as PUBMED, Science Direct, CINAHL, HINARI, Google Scholar, and local university repositories. Cochrane Q and I2 values were used to assess heterogeneity among the studies. Publication bias was assessed using funnel plots and Egger's test. The random-effects model was used to estimate the pooled prevalence. Results and conclusions: Of all the publications that were thoroughly searched, 9 studies with 2496 participants met the criteria for analysis. All of the studies were cross-sectionally designed and most of the studies used convenient sampling techniques. The included studies consisted of two conducted among adult patients diagnosed with CAP and living with HIV/AIDS, while the remaining seven studies were conducted among adult patients diagnosed with CAP without HIV/AIDS. The combined prevalence of bacterial causes of community-acquired pneumonia (CAP) among adult patients was found to be 39.18% (CI 36.34-42.02), with an I2 of 52.6 and a P value of 0.032. The primary bacterial cause was Klebsiella pneumoniae (9.1%), followed by Streptococcus pneumoniae (8.11%), and Staphylococcus aureus (6.8%). Therefore, it is advisable to introduce a diagnostic tool for identifying specific causative agents and drug resistance, which could lead to improved treatment and better patient outcomes by reducing the need for empirical treatments.
ABSTRACT
Background and Objectives: Antibiotic resistance is a significant problem that restricts the options for treating bacterial pneumonia. This research aimed to determine the bacterial causes of pneumonia and antibiotic resistance among hospitalized patients in southwest Ethiopia. Materials and Methods: We collected and analyzed 150 sputum samples from individuals with community-acquired pneumonia from April 1st to October 30th, 2019. Standard bacteriological procedures were used to identify the bacteria. Kirby Bauer's disk diffusion method was used to assess the bacteria's susceptibility patterns. Production of carbapenemase and extended-spectrum-lactamase were confirmed phenotypically. Odds ratios and the chi-square test were computed. Results: On the whole, bacterial pathogens were verified in 50% of the sputum samples. The predominant bacterial isolates were Klebsiella species, followed by Pseudomonas aeruginosa, Staphylococcus aureus and Streptococcus pneumoniae. About 77.5% of isolates were multidrug resistant. Moreover, 40.5% and 10.8% of the isolates were ESBL and carbapenemase producers, respectively. Aging, tobacco smoking, previous history of pneumonia, heart disease, and chronic respiratory disease had association with sputum culture-positivity. Conclusion: As a result, it is important to regularly monitor the bacterial etiologies and their patterns of resistance. Additionally, sociodemographic and clinical characteristics should all be taken into account while managing patients with pneumonia empirically in this context.
ABSTRACT
Introduction: Even though blood donation has increased in the past decades, it remains a challenge worldwide. An adequate blood supply can only be assured through voluntary blood donation. There is inadequate information on the level of blood donation practice in the current study area. This study aimed to assess the knowledge, attitude, practice, and associated factors toward voluntary blood donation among Hosanna town adult populations. Methods: A cross-sectional study was conducted from 1 May 2022 to 30 June 2022, on a total of 422 adult populations of Hosanna town. A simple random sampling technique was used to select the study subjects. Data were collected by face-to-face interviews using a structured pre-tested questionnaire. The levels of knowledge, attitude, and practice of participants toward voluntary blood donation were measured using a set of questions. Data were analyzed using SPSS version 25. Chi-square and odds ratios were calculated, and the results were presented with words and tables. Results: In this study, a total of 422 participants enrolled with a response rate of 96.6%. Of the total respondents, 204 (48.3%), 209 (49.5%), and 123 (29.15%) study participants had good knowledge, favorable attitude, and experience of blood donation, respectively. Participants' sex being male and having favorable attitudes were found to have significant associations with blood donation practice. Furthermore, it was found that male participants were more than two and a half times more likely to donate blood than female participants (AOR: 2.53; 95% CI: 1.54, 4.15). Those who had favorable attitudes were found more than three and a half times more likely to donate blood than those having unfavorable attitudes (AOR: 3.54; 95% CI: 1.32, 9.46). Conclusion and recommendations: A large proportion of adult populations had poor knowledge, unfavorable attitudes, and low practice toward voluntary blood donation. Therefore, local and national blood banks and transfusion agencies should design strategies that can be implemented to improve the knowledge or attitude of the adult population and motivate the population to donate blood voluntarily.
