ABSTRACT
AIMS: To compare the peripheral vasoconstrictor effects of ergotamine, rizatriptan, and their combination, in normal subjects. METHODS: This was a double-blind, four-way, crossover study. Sixteen young male volunteers, selected as responders to the vasoconstrictor effect of 0.5 mg ergotamine i.v., were administered 10 mg oral rizatriptan, 0.25 mg i.v. ergotamine, 10 mg oral rizatriptan+0.25 mg i.v. ergotamine, and placebo. The vasoconstrictor effect on peripheral arteries was measured with strain gauge plethysmography up to 8 h after dosing. The 8 h assessment period was divided into two 4 h intervals to assess the immediate (0-4 h) vs sustained effect (4-8 h) of treatment. RESULTS: For the 0-4 h interval, the decreases in peripheral systolic blood pressure gradients were: placebo (-1 mmHg [95% CI: -3, 1])Subject(s)
Arteries/drug effects
, Ergotamine/pharmacology
, Serotonin Receptor Agonists/pharmacology
, Triazoles/pharmacology
, Vasoconstriction/drug effects
, Vasoconstrictor Agents/pharmacology
, Adult
, Cross-Over Studies
, Double-Blind Method
, Drug Combinations
, Ergotamine/administration & dosage
, Ergotamine/adverse effects
, Heart Rate/drug effects
, Humans
, Male
, Migraine Disorders/drug therapy
, Serotonin Receptor Agonists/administration & dosage
, Serotonin Receptor Agonists/adverse effects
, Triazoles/administration & dosage
, Triazoles/adverse effects
, Tryptamines
, Vasoconstrictor Agents/administration & dosage
, Vasoconstrictor Agents/adverse effects