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1.
Ann Plast Surg ; 92(5S Suppl 3): S336-S339, 2024 May 01.
Article in English | MEDLINE | ID: mdl-38689415

ABSTRACT

BACKGROUND: Studies suggest an increasing trend of plastic surgeons choosing private practice after training, with up to 90% pursuing private practice without future fellowships.1 Previous data showed that 66.7% of graduates from plastic surgery residency programs chose to pursue private practice without future fellowship, while more recent studies estimate this statistic has risen close to 90%.1,2 The literature has yet to characterize the current plastic surgery workforce and changes in its composition over time. This study aims to analyze the characteristics and training of plastic surgeons in California through a comparative study with general surgeons. METHODS: Surgeon demographics were extracted from the Centers for Medicare and Medicaid Services open database. Urban/rural classification and academic affiliation were crosslinked from the Inpatient Prospective System database and sole proprietorship status was cross-linked from the NPI Registry. Summary statistics and logistic regressions with chi-squared analysis were analyzed using STATA/MP17. RESULTS: Our analysis consisted of 3871 plastic and general surgeons in California. Compared to general surgeons, plastic surgeons were less likely to be females (P < 0.000), and more likely to be sole proprietors (P < 0.000), and affiliated with a teaching hospital (P < 0.005). There was no statistically significant difference in the percentage of rural-practicing plastic and general surgeons (P = 0.590). More recent plastic surgery graduates were more likely to be affiliated with an academic hospital (P < 0.0000). The composition of females significantly increased from the older graduated cohort to the most recent one. There was no significant difference in sole proprietorship and rural practice status between the oldest and youngest graduating cohorts. CONCLUSIONS: Although the California plastic surgery workforce is gaining female plastic surgeons and shifting to academic institutions, significant progress in serving rural communities is yet to be made. Our study suggests that there may be a shift in the trend of plastic surgeons opting for private practice, possibly driven by a desire for more stable positions in academia. Continued improvement in diversity and training of future plastic surgeons is needed to alleviate the rural care gap.


Subject(s)
Surgery, Plastic , Humans , California , Surgery, Plastic/education , Surgery, Plastic/trends , Surgery, Plastic/statistics & numerical data , Female , Male , Private Practice/statistics & numerical data , Private Practice/trends , Career Choice , Surgeons/statistics & numerical data , Surgeons/trends , Adult , Middle Aged
2.
Aesthet Surg J Open Forum ; 4: ojac040, 2022.
Article in English | MEDLINE | ID: mdl-35747464

ABSTRACT

Background: The emphasis on better pain control with less narcotic use represents an ongoing challenge for outpatient plastic surgery procedures. Intravenous (IV) bolus opioids during surgery can lead to short-term relief, but often repeat dosing is required in the postanesthesia care unit (PACU), prolonging recovery time. The sufentanil sublingual tablet (SST) has recently shown efficacy in reducing overall opioid use and postsurgical recovery time for outpatient general surgery procedures. Objectives: To examine the effect of SST on PACU opioid use, adverse events, and recovery time compared with traditional IV opioid drug regimens in patients undergoing aesthetic surgical procedures. Methods: A retrospective chart review was performed on SST patients (n = 61) receiving a single 30 mcg SST 30 minutes before surgery (for short procedures) or 45 minutes before surgical extubation (longer procedures). A control group (n = 32) underwent similar surgical procedures utilizing standard IV opioid treatment without SST. Results: Control and study groups were of similar age and sex. Procedure duration (approximately 3 hours) and intraoperative opioid administration were similar in both groups, with 92% of patients receiving SST before extubation due to the length of the case. Almost all control patients (90.6%) required rescue opioids during recovery in the PACU compared with a few SST patients (16.4%; P < 0.001), averaging 5-fold higher dosing in the control group. Recovery duration did not differ between groups as factors other than pain management and adverse events affected discharge. Conclusions: SST substantially reduced opioid administration in the PACU for patients undergoing outpatient plastic surgery procedures.

3.
Aesthet Surg J Open Forum ; 4: ojab056, 2022.
Article in English | MEDLINE | ID: mdl-35350112

ABSTRACT

Background: Awake plastic surgery performed under minimal sedation has advantages including patient preference, affordability, and easier recovery compared to when performed under deeper sedation. Commonly used oral analgesics may not be adequate for awake procedures resulting in moderate to severe pain. Sufentanil sublingual tablet (SST) 30 mcg has been shown to provide timely analgesia with a safety profile appropriate for minimal-sedation settings. Objectives: To examine perioperative outcomes in patients who underwent awake plastic surgery with local anesthesia and SST 30 mcg for pain control. Methods: This study was a prospective single-group cohort study conducted at a single plastic surgery center. SST 30 mcg was administered approximately 30 minutes prior to the procedure. Outcome measures included the number of patients with adverse events, the number of patients requiring medications in the post-anesthesia care unit (PACU), and recovery time. Results: Among the 31 patients, the most common procedures were liposuction (71%), facelift (10%), and blepharoplasty (6%). The mean (± standard error [SE]) procedural duration was 81 ± 9 minutes. No vital sign instability or oxygen desaturation was observed. Three patients (10%) experienced nausea, only one of which required treatment with oral ondansetron 4 mg in the PACU. One patient (3%) experienced dizziness that did not require treatment. No patients required opioids or other analgesics in the PACU for pain. The mean (±SE) recovery time was 15 ± 4 minutes. Conclusions: Awake plastic surgery can be performed using SST 30 mcg with minimal side effects and a rapid recovery time.

4.
Plast Reconstr Surg ; 134(3): 536-546, 2014 Sep.
Article in English | MEDLINE | ID: mdl-24804638

ABSTRACT

BACKGROUND: Scarring represents a significant biomedical burden in clinical medicine. Mechanomodulation has been linked to scarring through inflammation, but until now a systematic approach to attenuate mechanical force and reduce scarring has not been possible. METHODS: The authors conducted a 12-month, prospective, open-label, randomized, multicenter clinical trial to evaluate abdominoplasty scar appearance following postoperative treatment with the embrace Advanced Scar Therapy device to reduce mechanical forces on healing surgical incisions. Incisions from 65 healthy adult subjects were randomized to receive embrace treatment on one half of an abdominoplasty incision and control treatment (surgeon's optimal care methods) on the other half. The primary endpoint for this study was the difference between assessments of scar appearance for the treated and control sides using the visual analogue scale scar score. RESULTS: Final 12-month study photographs were obtained from 36 subjects who completed at least 5 weeks of dressing application. The mean visual analogue scale score for embrace-treated scars (2.90) was significantly improved compared with control-treated scars (3.29) at 12 months (difference, 0.39; 95 percent confidence interval, 0.14 to 0.66; p = 0.027). Both subjects and investigators found that embrace-treated scars demonstrated significant improvements in overall appearance at 12 months using the Patient and Observer Scar Assessment Scale evaluation (p = 0.02 and p < 0.001, respectively). No serious adverse events were reported. CONCLUSIONS: These results demonstrate that the embrace device significantly reduces scarring following abdominoplasty surgery. To the authors' knowledge, this represents the first level I evidence for postoperative scar reduction. CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, II.


Subject(s)
Abdominoplasty , Bandages , Cicatrix/prevention & control , Postoperative Care/instrumentation , Postoperative Complications/prevention & control , Adolescent , Adult , Aged , Cicatrix/etiology , Female , Follow-Up Studies , Humans , Male , Middle Aged , Photography , Postoperative Care/methods , Prospective Studies , Treatment Outcome , Visual Analog Scale , Wound Healing , Young Adult
5.
Plast Reconstr Surg ; 120(7): 1886-1891, 2007 Dec.
Article in English | MEDLINE | ID: mdl-18090751

ABSTRACT

BACKGROUND: Postsurgical chronic empyema continues to present a complicated treatment scenario for thoracic and reconstructive surgeons. Muscle flaps are an important option in the management of complex thoracic wounds. This study was designed to report the Emory experience with muscle flaps for the management of complex postsurgical empyema. The authors also present their treatment algorithm for managing empyema thoracis. METHODS: The authors retrospectively reviewed the charts of 55 patients requiring different treatment modalities, including muscle flap transposition. Patients were divided into four groups according to the initial thoracic procedure: group A, no surgical resection; group B, postpneumonectomy; group C, postlobectomy; and group D, prophylactic postpneumonectomy or postlobectomy. The study included 42 men (76.4 percent) and 13 women with a mean age of 62 years (range, 39 to 77 years). RESULTS: Fifty-one muscle flap procedures were performed in 42 patients (serratus anterior flaps, 16 patients and 23 flaps; latissimus dorsi flaps, 16 patients and 18 flaps; pectoralis major muscle flaps, intercostal muscle flaps, and rectus abdominis flaps, three patients each: omental flap, one patient). The mean number of ribs resected before flap intervention, usually during the open window thoracostomy, was three. The average time from initial thoracic operation to flap intervention was 4 months. Average time from flap intervention to discharge was 12.5 days. Average hospital stay was 26.6 days. The 51 muscle flaps represented an average of 1.2 procedures per patient. CONCLUSION: Because of the excellent blood supply of extrathoracic muscle flaps and their ability to reach any place in the pleural cavity, they represent an ideal tissue with which to fill the contaminated pleural space.


Subject(s)
Empyema, Pleural/surgery , Pneumonectomy , Postoperative Complications/surgery , Surgical Flaps , Adult , Aged , Algorithms , Chronic Disease , Empyema, Pleural/etiology , Female , Humans , Male , Middle Aged , Postoperative Complications/etiology , Respiratory Tract Fistula/surgery , Respiratory Tract Infections/surgery , Retrospective Studies , Ribs/surgery , Surgical Flaps/blood supply , Thoracic Neoplasms/surgery , Thoracostomy , Treatment Outcome
6.
Plast Reconstr Surg ; 120(4): 1037-1044, 2007 Sep 15.
Article in English | MEDLINE | ID: mdl-17805133

ABSTRACT

BACKGROUND: The ability to predict postoperative lid levels in ptosis surgery has been refined over the years, but there is no completely predictable formula with which to predict the final tension in the upper lid that determines the final upper lid level. A significant percentage of patients continue to require postoperative surgical revision. The authors studied the effectiveness of a technique for the quantitation of aponeurotic repair that is not a measured resection procedure, does not require voluntary patient cooperation, and can be performed under general anesthesia. METHODS: The surgical technique involves reapproximation of specific anatomical landmarks, adjustment of upper lid level by eyelid gapping, and adjustment of upper lid tension with a spring-back test. Consecutive patient charts were reviewed retrospectively for age, sex, clinical examination, levator function, and outcomes, including revision rate and patient satisfaction. A total of 144 procedures were performed for 80 patients (64 bilateral and 16 unilateral). The series was reported for a 3-year period (2002 through 2005). The mean age was 62 years (range, 40 to 85 years). The average follow-up was 18 months. All patients had acquired adult ptosis with levator dehiscence and good levator function. RESULTS: The criterion for surgical revision was a greater than 1-mm asymmetry between the eyelids or patient dissatisfaction. Twelve patients (15 percent) were considered to be slightly asymmetric postoperatively, but only two (2.5 percent) exceeded the criterion and required surgical revision in the early postoperative period (<1 year). CONCLUSION: Tarso levator surgery can be performed under general anesthesia using a three-step technique to correct ptosis with a superior predictability.


Subject(s)
Blepharoplasty/methods , Blepharoptosis/surgery , Adult , Aged , Aged, 80 and over , Blepharoptosis/physiopathology , Eyelids/physiopathology , Eyelids/surgery , Female , Follow-Up Studies , Humans , Middle Aged , Patient Satisfaction , Retrospective Studies , Treatment Outcome
7.
Plast Reconstr Surg ; 120(1): 27-34, 2007 Jul.
Article in English | MEDLINE | ID: mdl-17572541

ABSTRACT

BACKGROUND: The muscle-sparing free transverse rectus abdominis muscle (TRAM) flap is a reliable technique that provides great versatility, with potentially decreased donor-site morbidity. However, because of the inherent nature of microvascular techniques, it is still regarded as a time-consuming and technically difficult procedure. The goal of this retrospective study was to document the validity of this technique in the private practice setting. METHODS: Data were reviewed retrospectively and included patient demographics, total operative time, choice of recipient vessels, outcome, and perioperative morbidities. RESULTS: One hundred one consecutive patients underwent 111 muscle-sparing free TRAM flap procedures for breast reconstruction (immediate, 89 patients; delayed, 12 patients). The internal mammary artery was used in 75 cases and the thoracodorsal artery was used in 36 cases. Average operative time was 185 minutes (3 hours 5 minutes). Average blood loss was 195 cc. There was no total flap loss. Revision of the microvascular anastomosis was performed in four patients, with flap salvage in all of them. Thirteen patients (13 percent) required primary mesh for abdominal wall closure. Fourteen (14 percent) had fat necrosis. Two patients had hematoma that required surgical evacuation. Abdominal wall weakness was detected in two patients (2 percent) and required mesh repair. CONCLUSIONS: The technical difficulties associated with the free TRAM flap have been ameliorated using a well-designed surgical plan and consistent technique performed by a team familiar with the procedure to achieve an acceptable average 3-hour operating time, with minimal complications. The authors advocate the muscle-sparing free TRAM flap as the operation of choice for unilateral breast reconstruction using autogenous tissue. The technique is expeditious and relatively safe.


Subject(s)
Mammaplasty/methods , Mammary Arteries/surgery , Surgical Flaps/blood supply , Thoracic Arteries/surgery , Adult , Aged , Anastomosis, Surgical , Blood Loss, Surgical/prevention & control , Esthetics , Evaluation Studies as Topic , Female , Follow-Up Studies , Humans , Middle Aged , Patient Satisfaction , Private Practice , Retrospective Studies , Time Factors , Treatment Outcome , Wound Healing/physiology
8.
Ann Plast Surg ; 57(5): 521-8, 2006 Nov.
Article in English | MEDLINE | ID: mdl-17060733

ABSTRACT

PURPOSE: Infected spinal stabilization devices represent a significant reconstructive challenge by threatening spinal stability and increasing the risk of neurologic complications. This study provides an anatomic and clinical investigation of posterior midline trunk reconstruction using paraspinous muscle flaps as the primary method of repair. METHODS: We retrospectively analyzed a series of 25 consecutive patients (mean age, 57.2 years; range, 32-78 years) with complex spinal wounds, reconstructed with paraspinous muscle flaps, at a single university healthcare system. To help define the versatility of these muscle flaps, we also performed cadaveric dissections with lead oxide injections in 10 specimens, with an emphasis on regional blood supply, flap width, and arc of rotation. RESULTS: From 1994 to 2000, we successfully reconstructed 25 patients with complex spinal wounds, using 49 paraspinous muscle flaps as the primary method of reconstruction. Hardware present in 22 patients was replaced or retained in 17 cases. Long-term spinal fusion with preservation of neurologic status was observed in all patients, with no cases of dehiscence or reinfection. Wound complications included cerebrospinal fluid leak (1), skin necrosis (1), sinus tracts (3), and seroma (2). Mean length of stay was 24 days (range, 8-57 days). One postoperative death occurred. Paraspinous dissections and injections confirmed a segmental type IV blood supply with medial and lateral perforators, arising from intercostal vessels superiorly and lumbar and sacral vessels inferiorly. Flap width was 8 cm at the sacral base, 5 cm at the level of the inferior scapular angle, and 2.5 cm at the first thoracic vertebra. CONCLUSIONS: Paraspinous muscle flaps can be used as the primary reconstructive option to cover and preserve spinal hardware, control local infection, and enable long-term spinal stabilization. Cadaveric dissections confirmed the usefulness of paraspinous flaps, which can be based upon lateral or medial perforators and can be safely mobilized to reliably reconstruct complex spinal wounds.


Subject(s)
Internal Fixators/microbiology , Internal Fixators/statistics & numerical data , Muscle, Skeletal/microbiology , Muscle, Skeletal/transplantation , Plastic Surgery Procedures/methods , Spine/surgery , Surgical Flaps/microbiology , Surgical Flaps/statistics & numerical data , Adult , Aged , Cadaver , Female , Humans , Male , Middle Aged , Postoperative Complications , Retrospective Studies , Risk Factors , Wound Healing
9.
Plast Reconstr Surg ; 117(4): 1325-33, 2006 Apr.
Article in English | MEDLINE | ID: mdl-16582808

ABSTRACT

BACKGROUND: The incidence of prosthetic graft infection is 1 to 6 percent, and the mortality rate of infected aortoiliac or aortofemoral bypass is 25 to 75 percent. The goal of this study was to report the use of muscle flaps in the management of patients presenting with infected vascular grafts. METHODS: A total of 22 patients required 26 muscle flaps to cover 24 infected vascular grafts. Muscle flaps were used for local wound control in all patients regardless of the fate of the graft. The vascular surgeons elected for graft salvage in eight of the 24 grafts. All of the muscle flaps survived. RESULTS: The average time interval between the bypass and infection was 371 days. One-month follow-up revealed an 88 percent salvage rate, but this decreased to 50 percent during the mean follow-up of 23 months. None of the patients originally managed with a salvaged graft lost a limb, and overall, 14 of 22 limbs in this series remained viable (64.0 percent). The mortality rate during the index hospitalization was 9 percent. In this series, suprainguinal grafts had a higher mortality rate. In addition, infection occurring more than 1 month postoperatively, culture-positive Pseudomonas and methicillin-resistant species, and exposure of the arterial-graft anastomosis were poor prognostic indicators of graft preservation. CONCLUSIONS: Management of infected vascular grafts remains a challenging problem. Muscle flap coverage should have a high priority, as the chance of a good outcome is highly favorable in early infections.


Subject(s)
Blood Vessel Prosthesis/adverse effects , Prosthesis-Related Infections/surgery , Surgical Flaps , Adult , Aged , Comorbidity , Female , Humans , Length of Stay , Male , Middle Aged , Prognosis , Prosthesis-Related Infections/epidemiology , Prosthesis-Related Infections/microbiology , Retrospective Studies , Wound Healing
10.
Ann Plast Surg ; 54(5): 471-6; discussion 477-8, 2005 May.
Article in English | MEDLINE | ID: mdl-15838205

ABSTRACT

The potential to extrapolate accurate data from 3-dimensional (3D) images of the breast is enormous and will greatly improve our ability to qualitatively determine differences in shape, size, and contour. The validity of these calculated measurements is important and needs to be determined before any meaningful data can be evaluated. PART I: Premastectomy 3D images (3dMD patient) were obtained on 19 breasts (14 patients). The volume of the mastectomy specimen was determined intraoperatively using water displacement. Two independent raters then calculated breast volumes using the 3D images and software, and these were compared with the intraoperative volume. Inter- and intrarater reliability was determined. Part II: Surface measurements (nipple to notch) were then evaluated on 20 breasts (10 patients) by comparing the 3D image determined distance to the known measurements. PART I: The average breast volume was 500 mL, compared with 489 mL for rater 1 and 490 mL for rater 2. The relative difference between the measured volume and the calculated volume for rater 1 and rater 2 was about -2%, with a standard deviation of +/- 13% to 16%. The coefficient of reproducibility for each reader was excellent, at 0.80 for rater 1 and 0.92 for rater 2. The level of agreement between the readers was also high at 0.975. Part II: The average nipple to notch measurement for each patient was 27.1 cm, compared the calculated average of 25.1 cm for rater 1 and 26.1 cm for rater 2. The mean relative difference between the measured and calculated distances for raters 1 and 2 was about -6%, with a standard deviation of +/- 6% to 7%. The level of agreement between readers was high, at 0.975. The ability to objectively determine breast volume and surface measurements using 3D imaging technology is now available with consistent and reproducible accuracy. Measurements are typically underestimated, with more variability when calculating volumes. Although inherent subjectivity will always exist when evaluating breast measurements, 3D technology provides invaluable information, particularly in the longitudinal evaluation of results.


Subject(s)
Breast/anatomy & histology , Image Processing, Computer-Assisted , Imaging, Three-Dimensional , Breast/surgery , Female , Humans , Mastectomy, Segmental , Observer Variation , Reproducibility of Results
11.
Ann Plast Surg ; 54(3): 231-5; discussion 235, 2005 Mar.
Article in English | MEDLINE | ID: mdl-15725819

ABSTRACT

The goal of this study is to obtain data concerning the incidence of capsular contracture and reoperation rates in patients having primary breast augmentation utilizing modern low-bleed smooth-wall silicone gel implants. Data were collected retrospectively and consisted of 44 patients who underwent primary breast augmentation using smooth silicone gel implants (Mentor Corporation) in the period between 2001 and 2003. Of the 131 patients identified, 44 patients fit the criteria of primary breast augmentation. Secondary cases and primary augmentation with mastopexy were excluded from this study. This group of patients is still followed, and the data are being updated periodically. A total of 44 patients underwent primary breast augmentation. Average age was 32 years (range, 19-57). Average follow-up was 34 months (range, 28-40). Average operative time was 52 minutes. The inframammary incision was used in 65% of patients and the areolar incision in 35%. The subglandular position was used in 35% of patients versus the submuscular position in 65%. Nine patients (20%) developed capsular contracture. Six patients (13.6%) had Baker 3 capsular contracture, which required revision. Four of the 9 patients with capsular contracture had implants placed in the submuscular space and 5 in the subglandular position. Relative to the implant position, 4 patients (9%) with implants placed in the submuscular position developed capsular contracture. Relative to the subglandular position, 5 patients (11.3%) with implants placed in the subglandular position developed capsular contracture. Eight patients (19%) required implant revision, 6 patients for capsular contracture, and 2 patients requested size change. Preliminary data from this study indicate that the use of the new generation of gel implants yields less capsular contracture, as well as decreased revision rates. Subglandular placement of gel implants did not significantly increase the risk of capsular contracture. Longer follow-up and multicenter studies are still needed to confirm these findings. This cumulative data could challenge the current status of gel implant moratorium imposed by the incidence of capsular contracture and revision rates.


Subject(s)
Breast Implants , Silicone Gels , Adult , Female , Follow-Up Studies , Humans , Postoperative Complications , Retrospective Studies
12.
Ann Plast Surg ; 52(3): 234-9, 2004 Mar.
Article in English | MEDLINE | ID: mdl-15156974

ABSTRACT

The use of endoscopic techniques in facial esthetic surgery has gained increasing popularity in the last decade. Endoscopic forehead rejuvenation became a reliable technique and an attractive option for both the surgeon and the patient. The use of the endoscope in face and neck lift surgery did not gain the same popularity, as explained by the relative few indications for this technique. In this study, we retrospectively review a series of 200 patients who underwent endoscopic-assisted face-lifts alone or in combination with other esthetic procedures. We divided the patients into 4 groups according to the type of incisions and the surgical approach used in each of them. We also reviewed the current status of using the endoscope in face and neck lift surgery. The technique described in this study uses limited access incisions (limited postauricular, submental, and temporal scalp) to reposition the ptotic facial elements, while avoiding the preauricular and postauricular scarring when indicated. Under endoscopic visualization, the composite face-lift flap elevates the malar fat pad above the zygomaticus muscle to the nasolabial fold. The lower-lid orbicularis oculi muscle is incorporated and lifted with composite flap through the lower blepharoplasty incision. The jowl area is contoured by tangential excision and tightening of the lateral platysma. Pretunneling and hydrodissection defines the plane of dissection and helps to reduce the bleeding during facial and cervical flap elevation. In this study, endoscopic techniques were applicable in selected patients undergoing facial rejuvenation with goals of decreased scarring. Indications for using the technique include young patients (eg, less than 50 years) with a relatively small amount of skin excess or older patients with thick skin and minimal skin redundancy. The technique is particularly attractive to the male patient, by avoiding the preauricular incision and the disruption of the beard line. Patients with excess skin underwent the standard cervicofacial incision. In this group the endoscope was used as a tool for better magnification and illumination.


Subject(s)
Endoscopy , Face/surgery , Rhytidoplasty/methods , Adult , Esthetics , Facial Muscles/surgery , Female , Humans , Male , Middle Aged , Retrospective Studies , Skin Aging/pathology , Treatment Outcome
13.
Plast Reconstr Surg ; 112(4): 1032-9, 2003 Sep 15.
Article in English | MEDLINE | ID: mdl-12973219

ABSTRACT

Despite the success with transverse rectus abdominis musculocutaneous (TRAM) flap breast reconstruction, ischemia-related complications, including fat necrosis and partial flap loss, continue to occur in 5 to 28 percent of reported series. The associated vascular problems of the TRAM flap stimulated several authors to study the effect of surgical delay, aiming to improve the viability of the flap. The present study investigated the potential effect of human vascular endothelial growth factor (hVEGF) in the induction of angiogenesis in the TRAM flap model and compared its effect with the surgical delay model. The rat model was used to demonstrate the effect of VEGF angiogenesis. Thirty male Sprague-Dawley rats were individually assigned to one of six groups (n = 5 in each group). One control group and five delay groups were established. A variety of flap delay techniques were used to increase the viable surface area of the flap. The flap mean viable surface area for the control group was 50 percent. The surgical delay group (group 2) had a mean viability of 83 percent. The group with the highest percentage of viable flap surface area was group 3, in which both surgical delay and intramuscular injection of VEGF were used (96.6 percent mean flap viability). The mean viable flap surface area in groups 4 (surgical delay and intraarterial VEGF), 5 (intramuscular VEGF), and 6 (intraarterial VEGF) were 90.6 percent, 87 percent, 90.6 percent, respectively. Statistically significant differences were obtained in all groups in comparison to the control group (p < 0.05). No significant differences were seen among the five treatment groups, however. The findings reported in the present study indicate that the use of VEGF to improve the viability of the TRAM flap proved to be beneficial and statistically significant in comparison to the control group.


Subject(s)
Endothelial Growth Factors/pharmacology , Graft Survival/drug effects , Intercellular Signaling Peptides and Proteins/pharmacology , Lymphokines/pharmacology , Neovascularization, Physiologic/drug effects , Rectus Abdominis/transplantation , Surgical Flaps , Animals , Humans , Male , Protein Isoforms/pharmacology , Rats , Rats, Sprague-Dawley , Time Factors , Vascular Endothelial Growth Factor A , Vascular Endothelial Growth Factors
14.
Plast Reconstr Surg ; 111(3): 1212-6, 2003 Mar.
Article in English | MEDLINE | ID: mdl-12621193

ABSTRACT

In this study, the effect of intramuscular injection of human vascular endothelial growth factor (hVEGF) on neovascularization following abdominoplasty was investigated. Twenty-four Sprague-Dawley rats were divided into four groups (n = 6). Two control groups and two experimental groups were established. Abdominoplasty was performed in all rats, with division of all the perforator vessels. In the control groups, normal saline was injected into the rectus abdominis muscle, and in the experimental groups, 100 microg of VEGF and normal saline were injected into the rectus muscle. A transverse rectus abdominis musculocutaneous (TRAM) flap was harvested on day 20 and day 40 in both the control and experimental groups. The range of viability of the TRAM flap was, respectively, 0 to 20 percent (mean, 6.7 percent) and 0 to 25 percent (mean, 14.2 percent) in both short-term and long-term control groups (no VEGF injected). The study (VEGF) group demonstrated a viability of 50 to 80 percent (mean, 70 percent) for the short-term group and 50 to 85 percent (mean, 72.5 percent) in the long-term group. No wound infection was documented, and there were no deaths during the study period. There was no statistically significant difference between the short-term and long-term divisions of the groups (p < 0.01); however, significant differences were observed between the control and experimental groups (p < 0.01). The authors concluded that VEGF injection after abdominoplasty improved the percentage of TRAM flap viability. This method of delay/revascularization could be used for the difficult problem of flap viability following abdominoplasty and for high-risk patients.


Subject(s)
Abdominal Wall/surgery , Endothelial Growth Factors/pharmacology , Intercellular Signaling Peptides and Proteins/pharmacology , Lymphokines/pharmacology , Neovascularization, Physiologic/drug effects , Surgical Flaps/blood supply , Animals , Male , Protein Isoforms/pharmacology , Rats , Rats, Sprague-Dawley , Tissue and Organ Harvesting , Vascular Endothelial Growth Factor A , Vascular Endothelial Growth Factors
15.
Ann Plast Surg ; 48(2): 173-9, 2002 Feb.
Article in English | MEDLINE | ID: mdl-11910223

ABSTRACT

The recent explosion of endoscopic techniques in plastic surgery has led to the successful harvest of a number of useful muscle flaps. The gracilis, rectus femoris, external oblique, and gastrocnemius muscles can all be harvested safely and reproducibly using endoscopic techniques. The aim of this study was to identify a safe and effective technique for endoscopic muscle flap harvest. Harvesting the gracilis muscle as a free flap and the gastrocnemius as a pedicle flap lends themselves best to the use of endoscopic techniques.


Subject(s)
Endoscopy/methods , Muscle, Skeletal/transplantation , Surgical Flaps , Tissue and Organ Harvesting/methods , Adult , Cadaver , Female , Humans , Male , Middle Aged , Models, Anatomic
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