1.
J Antibiot (Tokyo)
; 37(5): 431-40, 1984 May.
Article
in English
| MEDLINE
| ID: mdl-6547430
ABSTRACT
Two new acetylenic antibiotics, cepacins A and B, have been isolated from the fermentation broth of Pseudomonas cepacia SC 11,783 and assigned structures 1 and 2. Cepacin A has good activity against staphylococci (MIC 0.2 micrograms/ml) but weak activity against streptococci (MIC 50 micrograms/ml) and the majority of Gram-negative organisms (MIC values 6.3 approximately greater than 50 micrograms/ml). Cepacin B has excellent activity against staphylococci (MIC less than 0.05 micrograms/ml) and some Gram-negative organisms (MIC values 0.1 approximately greater than 50 micrograms/ml).
Subject(s)
Anti-Bacterial Agents/isolation & purification , Pseudomonas/metabolism , Anti-Bacterial Agents/pharmacology , Bacteria/drug effects , Fermentation , Lactones/isolation & purification , Lactones/pharmacology , Magnetic Resonance Spectroscopy , Molecular Conformation , Spectrophotometry, Ultraviolet
2.
J Antibiot (Tokyo)
; 37(4): 416-8, 1984 Apr.
Article
in English
| MEDLINE
| ID: mdl-6725147
3.
J Antibiot (Tokyo)
; 34(11): 1515-6, 1981 Nov.
Article
in English
| MEDLINE
| ID: mdl-6798006