Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters










Database
Language
Publication year range
1.
J Forensic Sci ; 65(1): 170-182, 2020 Jan.
Article in English | MEDLINE | ID: mdl-31211877

ABSTRACT

Forty-three fatalities involving the potent synthetic cannabinoid, 5-Fluoro-ADB, are summarized. For each case, a description of the terminal event, autopsy findings, cause of death, qualitative identification of 5-Fluoro-ADB and its ester hydrolysis metabolite, 5-Fluoro-ADB metabolite 7, in urine, and the quantitative values obtained in the blood specimens are outlined. Central blood concentrations ranged from 0.010 to 2.2 ng/mL for 5-Fluoro-ADB and 2.0 to 166 ng/mL for 5-Fluoro-ADB metabolite 7. Peripheral blood concentrations ranged from 0.010 to 0.77 ng/mL and 2.0 to 110 ng/mL for 5-Fluoro-ADB and 5-Fluoro-ADB metabolite 7, respectively. The majority of cases resulted in central to peripheral blood concentration ratios greater than 1 for 5-Fluoro-ADB (58%) and 5-Fluoro-ADB metabolite 7 (71%) suggesting that postmortem redistribution occurs to some extent. Combining the increased cardiac weight and/or gastric volume and toxicology data identifying 5-Fluoro-ADB, it is hypothesized that abuse of this substance may precipitate a dysrhythmia and cause sudden death.


Subject(s)
Illicit Drugs/blood , Illicit Drugs/urine , Indazoles/blood , Indazoles/urine , Marijuana Abuse/mortality , Adult , Chromatography, Gas , Chromatography, Liquid , Enzyme Multiplied Immunoassay Technique , Enzyme-Linked Immunosorbent Assay , Forensic Toxicology , Humans , Illicit Drugs/adverse effects , Indazoles/adverse effects , Male , Mass Spectrometry , Middle Aged , Molecular Structure , Myocardium/pathology , Organ Size , Stomach/pathology
SELECTION OF CITATIONS
SEARCH DETAIL
...