Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters










Database
Language
Publication year range
1.
J Diet Suppl ; 9(1): 19-33, 2012 Mar.
Article in English | MEDLINE | ID: mdl-22432800

ABSTRACT

Semecarpus anacardium commonly known as marking nut has been used in the Siddha system of medicine against various ailments. The antidiabetic and antioxidant potential of the drug was evaluated in Type 2 diabetic rats induced by feeding a high-fat diet (HFD) for 2 weeks followed by single intraperitoneal injection of streptozotocin (STZ) 35 mg/kg body weight. Three days after STZ induction, the hyperglycemic rats were treated with Semecarpus anacardium nut milk extract (SA) orally at a dosage of 200 mg/kg body weight daily for 30 days. Metformin (500 mg/kg body weight, orally) was used as a reference drug. The fasting blood glucose, insulin, Hb, HbA1c levels, and HOMA-IR and HOMA-ß were measured, and also the levels of lipid peroxidation and antioxidant enzymes were observed. SA significantly (p < .05) reduced and normalized blood glucose levels and also decreased the levels of HbA1c as compared with that of HFD STZ control group. SA treatment also significantly (p < .05) increased the levels of antioxidant enzymes while decreasing the levels of lipid peroxidation. The potential antihyperglycemic action and antioxidant role might be due to the presence of flavonoids in the drug.


Subject(s)
Antioxidants/therapeutic use , Blood Glucose/metabolism , Diabetes Mellitus, Experimental/drug therapy , Glycated Hemoglobin/metabolism , Hypoglycemic Agents/therapeutic use , Phytotherapy , Semecarpus/chemistry , Animals , Antioxidants/metabolism , Antioxidants/pharmacology , Diabetes Mellitus, Experimental/blood , Diet , Dietary Fats/adverse effects , Flavonoids/pharmacology , Flavonoids/therapeutic use , Hypoglycemic Agents/pharmacology , Lipid Peroxidation/drug effects , Male , Metformin/pharmacology , Metformin/therapeutic use , Nuts , Plant Extracts/pharmacology , Plant Extracts/therapeutic use , Rats , Rats, Sprague-Dawley
SELECTION OF CITATIONS
SEARCH DETAIL
...