[Immunological characteristics of patients with diffuse toxic goiter]. / Immunologicheskaia kharakteristika bol'nykh diffuznym toksicheskim zobom.

Altogether 24 patients with diffuse toxic goiter were examined after surgical intervention and thiamazole therapy. In addition to clinical methods the levels of T- and B-lymphocytes, immunoregulatory cells (T-helpers and T-suppressors) and immunoglobulins of different classes were determined before and after therapy. A method of spontaneous and complementary rosette formation and monoclonal antibodies (Ortho) were used for the determination of the content of T- and B-lymphocytes. Immunoglobulins were determined by a method of radial immunodiffusion in gel. It was shown that in patients with diffuse toxic goiter the level of T-lymphocytes was significantly on a decrease, the levels of B-lymphocytes and IgG were on an increase before therapy. There was sharp disturbance in the ratio of immunoregulatory cells--T-helpers and T-suppressors. After therapy the clinical picture and immunological indices in 14 patients returned to normal, in the rest of 10 patients the Ig level and ratio of immunoregulatory cells remained disturbed.

[Circulatory system reaction to loading tests in patients with the climacteric syndrome in relation to the phase of the climacteric and the presence of cardialgia]. / Reaktsiia sistemy krovoobrashcheniia na proby s nagruzkoi u bol'nykh s klimaktericheskim sindromom v zavisimosti ot fazy klimakteriia i nalichiia kardialgii.

Female patients with the menopausal syndrome (MS) manifestations showed a steeper increment of diastolic arterial blood pressure (ABP) and heart rate, as compared to normal subjects, in both phases of the menopause, irrespective of whether cardialgia was present or not; moreover, half of the patients showed negative electrocardiographic dynamics. Hemodynamic shifts in response to bicycle ergometry were similar in both menopausal phases and showed steeper increments in ABP and heart rate, as compared to those of normal subjects. Excessive ABP rise in response to exercise is mostly associated with cardialgias. Exercise-related ECG can usually improve or return to normal in premenopausal patients, while ischemic ST depression is associated with postmenopausal conditions. Physical working capacity of premenopausal women is only impaired in the presence of cardialgias, whereas that of postmenopausal women is reduced in the absence of cardialgia as well.