Lung Cancer Wherein Durvalumab Induced Both Anti-CRMP-5 Antibody-related Paraneoplastic Neurological Syndromes and Neurological Adverse Events.

A 68-year-old man with small-cell lung cancer developed anti-collapsin response-mediator protein (CRMP)-5 antibody-related paraneoplastic neurological syndrome (PNS) presenting with ataxia and chorea during treatment with durvalumab. As a result of steroid therapy, anti-CRMP-5 antibodies became negative, hyperintense lesions on brain magnetic resonance imaging disappeared, and neurological symptoms improved. After resuming durvalumab, he became unable to walk due to neurological adverse events (nAEs). There have been no reported cases manifesting PNSs and nAEs as a result of the same immune checkpoint inhibitors (ICIs) administered at different times. Resuming ICIs in patients diagnosed with PNSs should be performed with prudence.

Relationship between internet addiction and depression among Japanese university students.

BACKGROUND: Internet addiction (IA) has various adverse effects. We sought to elucidate the relationship between IA and depression among university students and to identify factors associated with IA. METHODS: Anonymous, self-administered questionnaires were distributed to 5,261 students and comprised basic characteristics, lifestyle habits, anxieties, the Internet Addiction Test (IAT), and the Center for Epidemiological Self-Depression Scale. RESULTS: Responses were obtained from 4,490 students (response rate: 85.3%). After excluding those with missing responses, 3,251 participants were analyzed (valid response rate: 61.8%). Logistic regression analysis with severity of IA as the independent variable and depression as the dependent variable revealed that the odds ratio (OR) for depression increased with severity of IA (mild addiction: OR=2.87, 95% confidence interval [CI]=2.45-3.36; severe addiction: OR=7.31, 95% CI=4.61-11.61). In a logistic regression analysis with mobile phone use as the independent variable and IA as the dependent variable, the highest OR was for message board use (OR=3.74, 95% CI=2.53-5.53) and the lowest OR was for use of LINE instant messenger (OR=0.59, 95% CI=0.49-0.70). Logistic regression analysis with academic department as the independent variable and internet addiction as the dependent variable revealed high ORs for the humanities department (OR=1.59, 95% CI=1.18-2.16) and fine arts department (OR=1.55, 95% CI=1.07-2.23). LIMITATIONS: The main limitations were the cross-sectional design, low valid response rate, single-university setting, and possible social desirability bias. CONCLUSIONS: Our results suggest a relationship between IA and depression in university students. IA tendency differed according to mobile phone use and academic department, suggesting these factors are associated with IA.

Point matching under non-uniform distortions and protein side chain packing based on an efficient maximum clique algorithm.

We developed maximum clique-based algorithms for spot matching for two-dimensional gel electrophoresis images, protein structure alignment and protein side-chain packing, where these problems are known to be NP-hard. Algorithms based on direct reductions to the maximum clique can find optimal solutions for instances of size (the number of points or residues) up to 50-150 using a standard PC. We also developed pre-processing techniques to reduce the sizes of graphs. Combined with some heuristics, many realistic instances can be solved approximately.