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1.
Transpl Int ; 18(1): 47-51, 2005 Jan.
Article in English | MEDLINE | ID: mdl-15612983

ABSTRACT

The purpose is to clarify risks of donation and quality of the donor's life after living-related donor liver transplantation (LDLTx). Sixty-eight donors were classified into four groups: lateral segment group (n = 30); left lobe group (n = 18); left lobe with the middle hepatic vein group (n = 11); right lobe group (n = 9). We investigated (i) the risks of donation, and evaluated the following: blood loss, operation time, postoperative liver function and duration of hospitalization; (ii) quality of donors' life: donors were mailed a structured questionnaire and the Short-Form Health Survey (SF-36), a generic measure assessing quality of life using eight scales. The results were: (i) there were no differences in liver function and duration of hospitalization between four groups; (ii) 48 donors (71%) responded. All donors returned to normalcy. The donors did not regret their decision to donate except two cases whose recipients had died. The donors' life was almost guaranteed regardless of the lobe we used as the graft.


Subject(s)
Hepatectomy/psychology , Liver , Living Donors/psychology , Quality of Life , Tissue and Organ Harvesting/psychology , Adult , Emotions , Follow-Up Studies , Functional Laterality , Health Status , Hepatectomy/adverse effects , Hepatectomy/mortality , Humans , Mental Health , Pain/epidemiology , Surveys and Questionnaires , Tissue and Organ Harvesting/adverse effects , Tissue and Organ Harvesting/methods
2.
Hepatogastroenterology ; 50(53): 1454-6, 2003.
Article in English | MEDLINE | ID: mdl-14571762

ABSTRACT

Gastrointestinal stromal tumors are non-epithelial neoplasms that arise from the gastrointestinal tract. Their variable cytologic atypia makes it difficult to predict their prognosis. We report a case of right hepatectomy for a giant metastasis detected 12 years after the surgical treatment of a rectal neoplasm, histologically demonstrated as a low-grade leiomyosarcoma initially, having morphological and immunohistochemical features of low malignancy. Histological examination of the hepatic metastases demonstrated that the tumors were composed of spindle cells similar to those in the rectal neoplasm. Immunohistochemical staining of the hepatic metastases with Ki-67 revealed stronger than the primary tumor. In conclusion, although histological and immunohistochemical analyses provide useful prognostic information, the prognosis of gastrointestinal stromal tumors is difficult to predict. Therefore, a patient with gastrointestinal stromal tumor diagnosed as low-grade malignancy requires carefully long-term follow-up.


Subject(s)
Liver Neoplasms/secondary , Rectal Neoplasms/pathology , Hepatectomy , Humans , Immunohistochemistry , Liver Neoplasms/diagnostic imaging , Liver Neoplasms/surgery , Magnetic Resonance Imaging , Male , Middle Aged , Prognosis , Rectal Neoplasms/surgery , Tomography, X-Ray Computed
3.
Transpl Int ; 16(4): 276-9, 2003 Apr.
Article in English | MEDLINE | ID: mdl-12730809

ABSTRACT

Familial hypercholesterolemia is a rare inherited disease with an incidence of approximately one per million. Severe hypercholesterolemia is observed from the time of birth onwards. It is associated with severe atherosclerosis in childhood, leading to death from myocardial infarction before the age of 20 years. Liver transplantation is the only effective treatment for this disease. We experienced the case of an infant aged 2 years 5 months who had homozygous familial hypercholesterolemia and who received a liver graft from his father, who had familial heterozygous hypercholesterolemia. The pre-operative plasma cholesterol level was >800 mg/dl. After liver transplantation, the recipient's cholesterol level decreased to 250 mg/dl after we administered the HMG-CoA reductase inhibitor. At present, 6 months after transplantation, the patient is doing well and free from a special diet. We can thus conclude that the combination therapy of liver transplantation from a donor with heterozygous familial hypercholesterolemia on cholesterol-lowering drugs is an effective therapy for a patient with the homozygous type of hypercholesterolemia.


Subject(s)
Hyperlipoproteinemia Type II/genetics , Hyperlipoproteinemia Type II/surgery , Liver Transplantation/pathology , Living Donors , Child, Preschool , Cholesterol/blood , Fathers , Genetic Carrier Screening , Hepatic Artery/pathology , Humans , Male , Postoperative Period
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