ABSTRACT
AIMS: To report early morphological changes and functional abnormalities in group 2A idiopathic juxtafoveolar retinal telangiectasis (IJRT) using spectral domain optical coherence tomography (SD-OCT) and microperimetry. METHODS: Six eyes (three patients; average age, 64 years) with group 2A IJRT were examined using SD-OCT and microperimetry. RESULTS: On SD-OCT, breaks in the highly reflective line, considered the boundary between the photoreceptor inner and outer segments, at the temporal to the fovea and corresponding to the telangiectasis lesions were observed in all eyes. Highly reflective tissue was observed in the outer retinal layer in five eyes. In three eyes with a right-angle venule, the outer retinal layer was replaced by the highly reflective tissue and was contiguous to the inner retinal layer. Microperimetry showed the reduction in the retinal sensitivity thresholds at the temporal to the fovea in five eyes. CONCLUSIONS: Early morphological alterations in group 2A IJRT in SD-OCT were observed. These finding might be visualisation of Müller cell abnormality on SD-OCT. At the same time, the disorder of photoreceptors occurs at the telangiectasis lesions from MP-1. Detailed observation of these abnormalities provides an understanding of the morphological and functional features of group 2A IJRT.
Subject(s)
Photoreceptor Cells, Vertebrate/pathology , Retinal Diseases/pathology , Telangiectasis/pathology , Tomography, Optical Coherence/methods , Aged , Female , Fluorescein Angiography/methods , Fovea Centralis/physiopathology , Humans , Male , Middle Aged , Ophthalmoscopy , Telangiectasis/physiopathology , Treatment Outcome , Visual Acuity/physiology , Visual Field Tests/methodsABSTRACT
PURPOSE AND OBJECTIVE: To report retina tomography after vitrectomy for macular edema in central retinal vein occlusion (CRVO). PATIENTS AND METHODS: Five patients with macular edema caused by CRVO were examined using optical coherence tomography (OCT) through their clinical courses. RESULTS: The retinal thickness through the fixation was reduced in all 5 eyes. Preoperatively, the retina thickness at the foveola was more than 500 microm in three eyes and more than 1000 microm in 2 eyes. The retina thickness was reduced to 311+80 microm within two weeks on average. Visual acuity was improved by two or more lines in 3 of 5 eyes. CONCLUSION: Vitrectomy is worthy of consideration when macular edemas are prolonged in patients of CRVO. OCT is a useful instrument for management and treatment of macular edema.
Subject(s)
Diagnostic Techniques, Ophthalmological , Macular Edema/surgery , Retina/pathology , Retinal Vein Occlusion/complications , Tomography/methods , Vitrectomy , Aged , Humans , Interferometry , Light , Macular Edema/etiology , Middle Aged , Visual AcuityABSTRACT
PURPOSE: We reviewed the records of 10 patients who had impending central retinal vein occlusion in order judge whether anticoagulant treatment with warfarin potassium (Warfarin) was indicated. PATIENTS: 6 men and 4 women, ranging in age from 25 to 83 (average 55) years were studied. RESULTS: Of 6 eyes, retinal hemorrhage disappeared completely within 6 months. Four patients whose visual acuity was 0.1 or less at one month needed photocoagulation. Four other patients whose late venous circulation time at fluorescein angiography improved within 30 seconds had good visual prognosis, 3 eyes of 4 patients aged 65 or older were not successful in regaining their visual acuity. CONCLUSION: Warfarin was not effective for patients who had clearly lost their visual acuity and the elderly in this series. Late venous circulation time at fluorescein angiography was a useful index for this treatment.
Subject(s)
Anticoagulants/therapeutic use , Retinal Vein Occlusion/drug therapy , Warfarin/therapeutic use , Adult , Aged , Aged, 80 and over , Female , Fluorescein Angiography , Humans , Male , Middle Aged , Retinal Vein Occlusion/physiopathology , Treatment Outcome , Visual AcuityABSTRACT
Inflammatory conditions of the eye may cause migration and proliferation of retinal pigment epithelium (RPE) cells. Therefore we evaluated the effects of prostaglandin E2 (PGE2) on cytosolic calcium ion concentration ([Ca2+]i) and on morphological changes in cultured bovine RPE cells. PGE2 caused an increase in [Ca2+]i, and contraction of RPE cells noted on phase-contrast biomicroscopy. The increase of [Ca2+]i was restrained by removing calcium ion from the medium and the addition of verapamil. Contraction of RPE cells was evaluated further by measuring the diffusion of 3H-dextran. The PGE2-induced increase in diffusion of 3H-dextran was suppressed by verapamil. We conclude that the contraction of RPE cells induced by PGE2 is dependent upon calcium ion transient and may be countered by calcium-blocking agents.
Subject(s)
Calcium/metabolism , Dinoprostone/pharmacology , Pigment Epithelium of Eye/drug effects , Animals , Cattle , Cells, Cultured , Dextrans/metabolism , Diffusion , Pigment Epithelium of Eye/cytology , Pigment Epithelium of Eye/metabolismABSTRACT
Nine eyes suffering from retinal detachment with giant tear were treated successfully by pneumatic retinopexy, followed by conventional buckling procedures and cryopexy. The retina in six of the nine eyes reattached after initial operation, whereas two required additional injection of SF6 gas. The remaining eye, having developed low-grade proliferative vitreoretinopathy (PVR C1), was treated successfully with vitrectomy. Visual outcome was rather poor immediately after the procedures due to vitreous opacity caused by gas injection. However, all cases showed excellent visual acuity five months after surgery. Visual field examined in six cases after surgery showed no significant constriction. If the retinal flap is mobile, pneumatic retinopexy may be effective in treating retinal detachment with giant tear.
