ABSTRACT
The results of examination of 58 patients in the course of multiple myeloma (MM) are discussed. Prognosis for LDH, beta2-m and FNO-alpha administration was evaluated versus immunochemical pattern, tumor mass and response to different chemotherapeutic regimens. High prognostic value of serum levels of LDH, beta2 and FNO-alpha in MM patients was observed. The method may be useful in carrying out chemotherapy and detecting recurrences and chemoresistance.
Subject(s)
Biomarkers, Tumor/blood , Multiple Myeloma/blood , Multiple Myeloma/immunology , Adult , Aged , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Female , Humans , L-Lactate Dehydrogenase/blood , Male , Middle Aged , Multiple Myeloma/drug therapy , Predictive Value of Tests , Prognosis , beta 2-Microglobulin/metabolismSubject(s)
Blood Transfusion/instrumentation , Hemofiltration/instrumentation , Micropore Filters , Animals , Blood Preservation , Charcoal , Dogs , Equipment Design , HumansABSTRACT
Stepwise desorption of protein components from the hemosorbent SCN after hemoperfusion was studied, and their molecular weights were determined. It was found that hard alkaline regeneration and oxidation with nitric acid do not affect the hemosorbent structure, composition and potentiometric characteristics. The regenerated hemosorbent can be successfully used for adsorbtion of extraneous low- and medium-molecular weight components to clarify microbiological liquids.
