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BMC Infect Dis ; 15: 60, 2015 Feb 14.
Article in English | MEDLINE | ID: mdl-25886914

ABSTRACT

BACKGROUND: The role of Mycoplasma hominis and M. genitalium in urogenital tract infections remains unknown. Furthermore these mollicutes present a complex relationship with the host immune response. The role of inflammatory cytokines in infections also makes them good candidates to investigate bacterial vaginosis and mycoplasma genital infections. Therefore, the aim of this study was to detect the above-mentioned mollicutes by quantitative Polymerase Chain Reaction (qPCR) methodologies in vaginal swabs and dosage of cytokines. METHODS: Vaginal swabs and peripheral blood were collected from 302 women, including healthy individuals. The molecular findings were correlated with some individual behavioral variables, clinical and demographic characteristics, presence of other important microorganisms in vaginal swabs, and levels of interleukin (IL)-1ß and IL-6. RESULTS: M. hominis and M. genitalium were detected in 31.8% and 28.1% of samples, respectively. The qPCR results were associated with clinical signs and symptoms of the infections studied. The frequency of Trichomonas vaginalis, Gardnerella vaginalis, Neisseria gonorrhoeae and Chlamydia trachomatis was 3.0%, 21.5%, 42.4%, and 1.7% respectively. Increased levels of IL-1ß were associated with the presence of M. hominis and signs and/or symptoms of the genital infection of women studied. CONCLUSION: IL-1ß production was associated with the detection of M. hominis by qPCR. The sexual behavior of women studied was associated with the detection of mycoplasma and other agents of genital infections.


Subject(s)
Mycoplasma Infections/epidemiology , Mycoplasma genitalium/isolation & purification , Mycoplasma hominis/isolation & purification , Urinary Tract Infections/epidemiology , Vaginosis, Bacterial/epidemiology , Adolescent , Adult , Aged , Brazil/epidemiology , Chlamydia Infections/epidemiology , Chlamydia Infections/microbiology , Chlamydia trachomatis/isolation & purification , Coinfection , Female , Female Urogenital Diseases/epidemiology , Female Urogenital Diseases/microbiology , Gardnerella vaginalis/isolation & purification , Humans , Middle Aged , Mycoplasma Infections/microbiology , Neisseria gonorrhoeae/isolation & purification , Prevalence , Sexually Transmitted Diseases/epidemiology , Sexually Transmitted Diseases/microbiology , Trichomonas vaginalis/isolation & purification , Urinary Tract Infections/microbiology , Urogenital System/microbiology , Vaginosis, Bacterial/microbiology , Young Adult
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