ABSTRACT
The article presents the results of psychological defense mechanism research of elderly persons group having mild cognitive impairments (51 persons). The leading defense mechanisms in this group were «reactive entity¼ and «denial¼. Reliable correlation between capacity of short-term memory, the MMSE test and «substitution¼, attention rate and «regression¼, leading psychological defense and indicators of anxiety, fear, depression and aggression of the studied group are found. The found correlation between defense tension and psychological parameters disclose features of intra personal adaptation of elderly persons having mild cognitive impairments. The received results can be used for psychological diagnostics and correction of emotional, personal and cognitive disorders of the elderly people.
Subject(s)
Cognitive Dysfunction/psychology , Defense Mechanisms , Adaptation, Psychological , Aged , Aggression/psychology , Anxiety/psychology , Cognitive Dysfunction/diagnosis , Denial, Psychological , Depression/psychology , Emotions , Fear/psychology , Humans , Memory, Short-TermABSTRACT
The article is devoted to investigation of unconscious aggression in patients with multiple sclerosis. We carried out comparison of the relative assessments of metabolism speed of glucose (according to positron emission tomography) and indicators of unconscious aggression (in the Hand test). It is shown that an increased tendency to open aggression (unconscious aggression) in patients with multiple sclerosis, is mainly linked with a reduction in the functioning of different departments of the frontal lobes of the brain on the left and with changes of the metabolism speed of glucose in the structures of the limbic system of the left and right hemisphere. With increasing of unconscious aggression we observed decrease of glucose metabolism speed in certain areas of the lower and middle frontal gyrus.
Subject(s)
Aggression , Frontal Lobe , Glucose/metabolism , Limbic System , Multiple Sclerosis , Positron-Emission Tomography , Adolescent , Adult , Female , Frontal Lobe/diagnostic imaging , Frontal Lobe/metabolism , Frontal Lobe/physiopathology , Humans , Limbic System/diagnostic imaging , Limbic System/metabolism , Limbic System/physiopathology , Male , Middle Aged , Multiple Sclerosis/diagnostic imaging , Multiple Sclerosis/metabolism , Multiple Sclerosis/physiopathology , RadiographyABSTRACT
AIM: Study previously unknown forms of persistence of Mycoplasma hominis in host organism. MATERIALS AND METHODS: Culture method was used for detection of mycoplasmas. Identification was carried out by serological, electron microscopy methods, classic PCR and real time PCR; circulating immune complexes (CIC) were isolated by PEG precipitation. RESULTS: Classic micoplasma cultures could not be isolated from blood even once. At the same time "mini-colony" cultures composed of mini-cells that were hardly passaged but sometimes formed continuous layer of the same colonies were isolated from blood serum samples with high frequency. During reseeding for more than 1 year they never acquired classic form. Not only antigens of M. hominis but its DNA were shown to be present in CIC. Viable cells forming "mini-colonies" identical to those isolated from blood sera were isolated from circulating immune complexes. A system of evidence on identity of isolated M. hominis cultures is presented. Cultures had infectivity and an ability to persist in organs of experimentally infected mice. CONCLUSION: The isolated forms are apparently the result of adaptation of mycoplasmas to humoral immunity factors.
Subject(s)
DNA, Bacterial/analysis , Mycoplasma Infections/blood , Mycoplasma hominis/genetics , RNA, Ribosomal, 16S/analysis , Adaptation, Physiological/immunology , Animals , Antigen-Antibody Complex/blood , Chemical Precipitation , Humans , Immunity, Humoral , Mice , Microscopy, Electron , Mycoplasma Infections/immunology , Mycoplasma Infections/microbiology , Mycoplasma hominis/isolation & purification , Mycoplasma hominis/pathogenicity , Polyethylene Glycols/chemistry , Real-Time Polymerase Chain ReactionABSTRACT
To study mechanisms of development of cognitive dysfunctions in multiple sclerosis (MS), brain glucose metabolism has been investigated using PET method. We have studied 61 patients with different types of MS course. Correlations between cognitive dysfunctions and regional glucose metabolic rate were revealed. The authors suggest that metabolic dysfunctions of the grey matter play the important role in the pathogenesis of cognitive disturbances in MS.
Subject(s)
Brain/metabolism , Cognition Disorders/metabolism , Glucose/metabolism , Multiple Sclerosis, Chronic Progressive/complications , Multiple Sclerosis, Relapsing-Remitting/complications , Adult , Cognition Disorders/etiology , Female , Humans , Male , Multiple Sclerosis, Chronic Progressive/psychology , Multiple Sclerosis, Relapsing-Remitting/psychology , Positron-Emission Tomography , Young AdultABSTRACT
The article is devoted to the study of psychological characteristics in patients with multiple sclerosis and their role in treatment and rehabilitation. The polymorphic fluctuating psychological disorders (cognitive and personality disorders, neuropsychological symptoms and inadequate "internal picture of disease") were found. The characteristics of unconscious psychic activity were specified. It was supposed that not only psychological factors but also functional state of the brain underlie the peculiarity of psychological disorders in patients with multiple sclerosis. The interdependence of psychological and cerebral factors influences the interference between clinical and psychological presentations in patients and must be taken into consideration in the treatment and rehabilitation of multiple sclerosis.
