1.
J Med Chem
; 24(6): 742-8, 1981 Jun.
Article
in English
| MEDLINE
| ID: mdl-7252983
Subject(s)
Amino Acids , Hypersensitivity/drug therapy , Oxamic Acid/analogs & derivatives , Administration, Oral , Animals , Male , Oxamic Acid/administration & dosage , Oxamic Acid/chemical synthesis , Oxamic Acid/pharmacology , Passive Cutaneous Anaphylaxis/drug effects , Rats , Structure-Activity Relationship
2.
J Med Chem
; 24(6): 748-52, 1981 Jun.
Article
in English
| MEDLINE
| ID: mdl-7252984
3.
J Med Chem
; 18(9): 926-33, 1975 Sep.
Article
in English
| MEDLINE
| ID: mdl-1159715
ABSTRACT
A large number of oxanilic acid esters and N-heteroaryl oxamic acid esters were prepared and found to have antiallergic activity using the rat passive cutaneous anaphylaxis (PCA) test. Many of the oxanilic acid esters are active orally, with the most active species having an aryl 2'-carbamoyl group and a 3'-methoxy group. Hydrolysis of the ester from the oxanilic ester moiety causes a loss of oral activity.