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Antimicrob Agents Chemother ; 38(4): 853-6, 1994 Apr.
Article in English | MEDLINE | ID: mdl-8031058

ABSTRACT

Alpha interferon (IFN-alpha) and acyclovir (ACV) are synergistic in their anti-herpes simplex virus activities. IFN-alpha treatment reduced the herpes simplex virus thymidine kinase (TK) activity present in cells 6 h postinfection, while steady-state levels of TK mRNA remained at or above the amount in infected, untreated cells. The inhibition of TK production by IFN-alpha treatment appeared to be transient and translational, not transcriptional.


Subject(s)
Acyclovir/pharmacology , Herpesvirus 1, Human/enzymology , Interferon-alpha/pharmacology , Thymidine Kinase/metabolism , Animals , Blotting, Western , Cell Line , Drug Synergism , Humans , Interferon alpha-2 , Luminescent Measurements , Protein Biosynthesis/drug effects , RNA, Viral/biosynthesis , Recombinant Proteins , Thymidine Kinase/antagonists & inhibitors , Thymidine Kinase/biosynthesis , Transcription, Genetic/drug effects , Vero Cells , Viral Envelope Proteins/biosynthesis
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