[Functional significance of the thyroid gland]. / Funktsional'noe znachenie shchitovidnoi zhelezy.

On the basis of literature data and our own findings, the paper presents the current concepts of the production, secretion, transport, catabolism, mechanisms of action, and effects in the organism of thyroid hormones during eu-, hypo-, and hyperthyrosis. The nervous, humoral, and immune mechanisms of regulation of the secretory activity of the thyroid gland and changes in its functional activity in ontogenesis are discussed.

[The dependence of the temperature response to pyrogens on the ambient temperature and the initial body temperature]. / Zavisimost' temperaturnogo otveta na pirogeny ot temperatury okruzhaiushchei sredy i iskhodnoi temperatury tela.

The dependence of the temperature response to injection of Freund's complete adjuvant (FCA) containing killed and dried Mycobacterium butyricum on ambient temperature within 8-10, 14-16, 20-22, 26-28 degrees C ranges and initial body temperature was studied in experiments on rats, guinea pigs, and rabbits. The duration of the hyperthermic response was maximal at an ambient temperature 14-16 degrees C, and its dynamics can be divided in 2 phases, initial febrile and subsequent subfebrile. An increase in rectal temperature after application of the agent was the higher the lower was its initial value and vice versa. The hyperthermic response to FCA did not occur at 8-10 degrees C.

[Change in the content of alpha-fetoprotein and sex steroid hormones in the blood of rabbits in fever or subnormal temperature]. / Izmenenie soderzhaniia alpha-fetoproteina i polovykh steroidnykh gormonov v krovi u krolikov pri likhoradke i subfebrilitete.

In experiments on rabbits, changes in the content of alpha-fetoprotein, estradiol and progesterone in blood serum in fever and subnormal temperature simulated with the use of pyrogenal and Freund's complete adjuvant were studied. The concentration of alpha-fetoprotein decreased and that of estradiol and progesterone increased. The results were analyzed in terms of the return of certain signs and properties in disease to the period of antenatal ontogenesis. A possible relation between the changes in alpha-fetoprotein in fever, subnormal temperature and immune, hormonal mechanisms of the thermoregulatory disorder was hypothesized.

[Sexual differences in the development of a hyperthermic reaction in rats after the administration of Freund's complete adjuvant]. / Polovye razlichiia v razvitii gipertermicheskoi reaktsii u krys posle vvedeniia polnogo ad''iuvanta Freinda.

Application of Freund's complete adjuvant containing killed and dried Mycobacterium butyricum led to a two-phase hyperthermic response in white rats, much more obvious in female than in male rats. The difference seems to be due to a more obvious increase of the tumour necrosis alpha-factor, progesterone, and thyrotropic hormone in the blood of female rats, as well as to prevalence of pyretic activity over the pyretic one in them.

[The problem of the effect of cosmogeophysical factors on the formation of the properties of developing organisms during early ontogeny]. / Problems vliianiia kosmogeofizicheskikh faktorov na formirovanie svoistv razvivaiushchikhsia organizmov v period rannego ontogeneza.

The paper is dedicated to a poorly understood but highly perspective direction of modern biology and medicine, namely, to the elucidation of bioinformative role of the natural physical cosmoplanetary fields. The problem associated with the phenomenon of heliomagnetic imprinting, the effect of heliogeophysical factors on developing organism has been touched on. There present the literature data pointing to existing the dependence of a number of morphofunctional properties as well as some peculiarities of human body pathology on when the pregnancy and labor occurred which in particular can be related to the changes in the field structure of the biosphere depending upon the space processes dynamics.

[The problem of the influences of brain cholinergic mechanisms on lipoprotein metabolism in disorders of heat exchange and in emotional stress]. / Problema vliianii kholinergicheskikh mekhanizmov mozga na obmen lipoproteidov pri narusheniiakh teploobmena i pri émotsional'nom stresse.

The contribution of central cholinoreactive systems to the control of plasma lipoprotein metabolism was studied in white rats exposed to cold, overheating and immobilization stress. Possible mechanisms of shifts in fatty-acid composition, as well as high-density lipoprotein cholesterol and total very low and low density lipoproteins, associated with hypothermia, hypertermia and emotional stress under conditions of excitement and blockade of cerebral m- and n-cholinoreceptors, are discussed. Changes in hypothalamic acetylcholin metabolism in stress-exposed animals are demonstrated. It is suggested that central cholinoreactive systems may play an important role in the control of adaptive metabolic reactions involving composite lipids under exposure to low and high environmental temperatures and emotion factors.