1.
Bioorg Khim
; 33(5): 527-37, 2007.
Article
in Russian
| MEDLINE
| ID: mdl-18050658
ABSTRACT
Isosteric triphosphonate derivatives of 2',3'-dideoxy-2',3'-didehydroadenosine and 3'-deoxy-2',3'-didehydrothymidine and their beta,gamma-substituted analogues were synthesized. Their substrate properties toward a number of reverse transcriptases of the human immunodeficiency and bird myeloblastosis viruses, human DNA polymerases alpha and beta, and the Klenow fragment of Escherichia coli DNA polymerase I were studied.
Subject(s)
Adenosine Monophosphate/analogs & derivatives , DNA-Directed DNA Polymerase/chemistry , Deoxyadenine Nucleotides/chemistry , Dideoxynucleotides/chemistry , Organophosphonates/chemistry , Stavudine/analogs & derivatives , Adenosine Monophosphate/chemistry , Animals , Dideoxynucleotides/chemical synthesis , Humans , Stavudine/chemistry , Substrate Specificity
2.
Gig Sanit
; (3): 81-3, 1990 Mar.
Article
in Russian
| MEDLINE
| ID: mdl-2143495
