Subject(s)
History, 20th Century , History, 21st Century , Argentina , Biomedical Research/trends , Humans , Universities/trendsSubject(s)
Humans , History, 20th Century , History, 21st Century , Universities/trends , Argentina , Biomedical Research/trendsABSTRACT
The lack of responsiveness to self and non-self Ags is normally maintained by multiple mechanisms, including the suppressive activities of several T cell subsets. In this study, we show that CD8(+) T cells from both adult peripheral blood and umbilical cord blood mononuclear cells constitutively expressing HLA-DR represent a natural human CD8(+) regulatory T cell subset. Their suppressive effect appears to be cell-to-cell contact dependent and may involve CTLA-4 signaling between neighboring T cells. These regulatory T cells can be expanded in vitro and exhibit a suppressive capacity similar to that observed in ex vivo CD8(+)HLA-DR(+) T cells. The high frequency of CD8(+)HLA-DR(+) T cells that we detected in patients with non-small cell lung cancer deserves further work to confirm their putative suppressor effect within the tumor.
Subject(s)
CD8-Positive T-Lymphocytes/metabolism , HLA-DR Antigens/metabolism , Phenotype , T-Lymphocyte Subsets/metabolism , T-Lymphocytes, Regulatory/metabolism , Aged , Aged, 80 and over , CD8-Positive T-Lymphocytes/immunology , CTLA-4 Antigen/immunology , CTLA-4 Antigen/metabolism , Carcinoma, Non-Small-Cell Lung/immunology , Carcinoma, Non-Small-Cell Lung/pathology , Cell Communication , Cell Proliferation/drug effects , Female , Fetal Blood/cytology , HLA-DR Antigens/immunology , Humans , Immunomodulation , Immunophenotyping , Infant, Newborn , Interleukin-2/pharmacology , Leukocytes, Mononuclear/immunology , Leukocytes, Mononuclear/metabolism , Lymphocyte Activation/immunology , Lymphocyte Count , Male , Middle Aged , T-Lymphocyte Subsets/immunology , T-Lymphocytes, Regulatory/immunologyABSTRACT
Al igual que Mathieu Delarue, (¿quizás un mateo de la calle?) hemos dudado en tomar la decisión de escribir o no esta carta. Prevaleció el deseo de aclarar y quizás aportar algunas precisiones al Editorial de la Dra Quadrelli ya que al decir de Fancis Bacon, "la verdad surge más fácilmente del error que de la confusión"
