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Vopr Med Khim ; 45(6): 514-24, 1999.
Article in Russian | MEDLINE | ID: mdl-10761218

ABSTRACT

Using experimental transcription model in vitro, and method of electron-topological calculations the elements of pharmacological and structural community have been found in the groups of physiologically active compounds (PAC), blocking and activating external cellular receptors. This finding confirms the necessity of subdivision special groups of bio-substrates blockators and activators for hierarchical classification, of PAC.


Subject(s)
Ligands , Receptors, Cell Surface/agonists , Receptors, Cell Surface/antagonists & inhibitors , Animals , Humans , Protein Binding , Receptors, Cell Surface/physiology , Signal Transduction , Structure-Activity Relationship , Transcription, Genetic
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