Directed Calf Raising in the Conditions of Adaptive Technology.

For the first time, based on complex research, a zoo technical justification for the use of PS-2 and PS-4 biostimulators in the technology of calf raising in individual boxes and pavilions is given to activate the body's adaptogenesis to cold and implement the productive qualities of young stock during rearing and fattening in typical premises. Intramuscular injection of PS-2 (polysaccharide complex of yeast cells immobilized in an agar gel by adding a benzimidazole derivative) and PS-4 (similar to PS-2 plus antibiotic of the cephalosporin) to calves in a dose of 3 ml at 2-3 and 7-9 days of life stimulates their growth and development during the raising, rearing, and fattening periods, thereby reducing the incidence of diseases. By the end of the growing, rearing, and fattening periods, the animals of the 1st and 2nd experimental groups outnumbered their control peers by 7.2 and 8.2 kg; 11.4 and 13.6 kg; as well as 13.8 and 16.8 kg, respectively (P<0.05-0.01). A similar pattern occurred in the nature of changes in exterior measurements and growth coefficient of animals of the compared groups. At the same time, in the calves of the 1st and 2nd experimental groups, respiratory and digestive diseases were reduced by 2.0 and 4.0 times, the recovery time was decreased by 3.47 and 5.12 days, and the Mellenberg coefficient was reduced by 3.7 and 12.1 times, compared to the control group (P<0.05). It was found that PS-2 and PS-4 increased the pre-slaughter weight of the young stock by 14.6 and 18.0 kg, the weight of the hot carcass by 12.8 and 15.8 kg, and the slaughter weight by 13.7 and 16.5 kg (P<0.05-0.01). Moreover, the weight of the half-carcasses of the young stock of the experimental groups, compared to the control group, was higher by 6.7 and 8.7 kg, the yield of meat by 5.4 and 6.9 kg, and of bones by 0.6 and 1.0 kg (P<0.05-0.001). With an increase in the weight of half-carcasses of the experimental animals, the specific weight of the meat increased, and the bones, on the contrary, decreased. Furthermore, the yield of meat of the highest and first grades in the animals of the experimental groups increased on the background of intramuscular injection of biostimulators when using PS-2 (by 0.6 and 0.3%; P<0.01) and PS-4 (by 0.9 and 1.1%; P<0.01). However, the second grade decreased by 0.9 and 2.0% (P>0.05), compared to the control group.

Three-point multivariate calibration models by correlation constrained MCR-ALS: A feasibility study for quantitative analysis of complex mixtures.

When it comes to address quantitative analysis in complex mixtures, Partial Least Squares (PLS) is often referred to as a standard first-order multivariate calibration method. The set of samples used to build the PLS regression model should ideally be large and representative to produce reliable predictions. In practice, however, the large number of calibration samples is not always affordable and the choice of these samples should be handled with care as it can significantly affect the accuracy of the predictive model. Correlation constrained multivariate curve resolution (CC-MCR) is an alternative regression method for first-order datasets where, unlike PLS, calibration and prediction stages are performed iteratively and optimized under constraints until the decomposition meets the convergence criterion. Both calibration and test samples are fitted into a unique bilinear model so that the number of calibration samples is no longer a critical issue. In this paper we demonstrate that under certain conditions CC-MCR models can provide for reasonable predictions in quantitative analysis of complex mixtures even when only three calibration samples are employed. The latter are defined as samples having the minimum, the maximum and the average concentration, providing for a simple and rapid strategy to build reliable calibration model. The feasibility of three-point multivariate calibration approach was assessed with several case studies featuring mixtures of different analytes in presence of interfering species. Satisfactory predictions with relative errors in the range 3-15% were achieved and good agreement with classical PLS models built from a larger set of calibration samples was observed.

[Using medical compulsory measures in the treatment of patients with traumatic epilepsy, who committed social dangerous actions].

There were examined 120 patients with traumatic epilepsy which had done SDA and hadn't been found guilty apropos of this. Depending on dynamics of epilepsy, all patients were divided into two groups--with favourable passing and unfavourable passing of the disease. There were found out clinical and social factors that influence the level of social danger of recognized deranged patients, that being taken into consideration allows to make differential choice of specific types of compulsory measures to definite category of patients.

[Early leukemia effect during chronic exposure to radiation with high doses].

The preliminary results of the analysis of leukemia morbidity in the sub-cohort of workers from PA "Mayak" exposed with high (more than 4Gy) doses during relatively short time range (few years) have been obtained in terms of materials from the medical-dosimetry register (SUrIBPh). The earlier dynamics of the leukemia morbidity implementation (2-5 years after the beginning of exposure) was established for this sub-cohort, in contrast to that predicted on the base of examination of the cohort of atomic bombardment victims from Japan cities (LSS). The "'early" leukemia effect is connected with intensive cell death and has a threshold nature. It could be supposed, that intensification of born-marrow hematopoetics restricts a potential of reparation processes and leads to earlier (in contrast with that observed in the LSS cohort) implementation of carcinogenetic effect. Using propositions developed to describe the process of the creation of consecutive specific stable mutation in the target cells, the options is proposed of multistage model, which allows the prediction of post-radiation dynamics of leukemia morbidity intensity. Both data from LSS(DS86) and from the register for workers from PA "Mayak" were used to asses the model parameters. The satisfactory agreement is illustrated between the observed dynamics of leukemia morbidity and the model calculations.

[The forensic psychiatric expertise of patients with epilepsy of traumatic origin and moderately pronounced mental disorders]. / Sudebno-psikhiatricheskaia ékspertiza bol'nykh épilepsiei travmaticheskogo geneza s umerennoi vyrazhennost'iu psikhicheskikh rasstroistv.

A total of 17 patients were examined with epilepsy of traumatic genesis presenting with moderately severe mental disorder and unfavourable course of the illness. Criteria were defined more exactly of forensic psychiatric assessment of chronic mental disorders in this most challenging "borderline" (in the expert respect) group of patients. Established in these cases were conditions of use of juristical (psychological) criterion of the diminished responsibility formula: the presence of manifest changes in the personality with moderately severe ("borderline") deterioration of intellect, social and occupational disadaptation, predominance of psychopathological mechanisms in behaviour of patients including those during their committing illegal actions, rapidly progredient type of epilepsy course, and chronic alcoholism going in with the underlying condition.