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Radiats Biol Radioecol ; 48(2): 195-8, 2008.
Article in Russian | MEDLINE | ID: mdl-18666652

ABSTRACT

The action of natural (garlick extract, retinol) and of synthetic (crown-compound) antimutagenes in lymphotytes with gamma-radiation-induced inhibition of DNA-damages repair in cases of Elers-Danlos, syndrom, progeria and gomocystinurea was studied. Antimutagen cells defence from mutagenes was shown at all cases except one: progeria cells treated by retinol. Thus the repair-deficient cells resistance against mutagenes could be increased by antimutagenes.


Subject(s)
Antimutagenic Agents/pharmacology , Crown Compounds/pharmacology , DNA Damage/drug effects , DNA Repair/drug effects , Garlic , Plant Extracts/pharmacology , Vitamin A/pharmacology , Cadmium Chloride/adverse effects , Cells, Cultured , Crown Compounds/chemical synthesis , DNA Damage/radiation effects , Ehlers-Danlos Syndrome/genetics , Gamma Rays/adverse effects , Garlic/chemistry , Homocystinuria/genetics , Humans , Lymphocytes , Progeria/genetics
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